At the IGTP TODAY

News

- Research

Impact of ceiling of care on mortality across four COVID-19 epidemic waves in Catalonia

Researchers from IGTP analysed in-hospital mortality in 5,813 COVID-19 patients across four epidemic waves in Catalonia, focusing on whether patients had a ceiling of care. Mortality decreased significantly over time for patients without a ceiling of care, but remained consistently high in those with one. These findings underscore the need to account for ceiling of care when evaluating COVID-19 outcomes and planning future healthcare responses.

FOXP4 gene identified in the first large-scale genetic study on Long COVID with participation of the GCAT

New insights into the complexities of Long COVID have been brought to light, thanks to an international collaborative effort with the participation of researchers from GCAT|Genomes for life, a strategic project of IGTP. A study published today in Nature Genetics used the vast data from the COVID-19 Host Genetics Initiative to perform the first study examining the entire genetic code specifically focused on Long COVID.

- Research

According to a study by the Inflammatory Bowel Disease Research Group, severe obesity is a risk factor for developing Crohn’s disease and ulcerative colitis

This is the main conclusion of a study that analysed data over a fifteen-year period from one million individuals in Catalonia with obesity, severe obesity, or who had undergone bariatric surgery. Crohn's disease and ulcerative colitis are the main inflammatory bowel diseases, affecting around 100,000 people in Catalonia, which today marks World IBD Day.

- Research

A new cell model to advance research into NF2-related schwannomatosis

A study led by the Clinical Genomics Unit (UGC) has established a new cell model to advance research into NF2-related schwannomatosis (SWN-NF2), a rare genetic disease. The work, published in the journal Genes & Disease, describes the generation and characterisation of cell spheroids derived from induced pluripotent stem cells (iPSC)-a type of stem cell capable of transforming into almost any cell type-that reproduce the alterations observed in tumours associated with the disease.

- Research

HDAC11 deficiency improves muscle function and regeneration during ageing

Researchers from GRENBA-IGTP have identified the HDAC11 protein, an enzyme involved in cellular regulation, as a new therapeutic target to combat sarcopenia, the loss of muscle mass associated with ageing. The study shows that HDAC11 deficiency reduces muscle atrophy, preserves the muscle stem cell reservoir, promotes regeneration after injury and improves muscle function, opening the door to new strategies to support healthy ageing.