At the IGTP TODAY
The first CORE IGTP Scientific Conference was held at the Badalona International Business Centre (BCIN), an initiative of the CORE Program that aims to establish itself as an annual space for meeting, debate and scientific exchange among professionals involved in population health research.
Researchers from ICREC-IGTP have conducted a preclinical study on the effects of the drug empagliflozin, alone or in combination with sacubitril/valsartan, in the early phase following a myocardial infarction. The combination of the two showed promising results.
Researchers from the Experimental Tuberculosis Unit (UTE) at the IGTP and the Germans Trias i Pujol University Hospital have published a study in Nature Communications in which, for the first time, the transcriptomic profile of human tuberculosis lung lesions is correlated with clinical data from the same patients.
Researchers from IGTP analysed in-hospital mortality in 5,813 COVID-19 patients across four epidemic waves in Catalonia, focusing on whether patients had a ceiling of care. Mortality decreased significantly over time for patients without a ceiling of care, but remained consistently high in those with one. These findings underscore the need to account for ceiling of care when evaluating COVID-19 outcomes and planning future healthcare responses.
IGTP’s strategic project GCAT|Genomes for Life has published a study in the journal Scientific Reports proposing a method to correct selection biases in population-based cohorts. The study represents a significant step forward in improving the reliability of data derived from such studies for public health research and precision medicine.
New insights into the complexities of Long COVID have been brought to light, thanks to an international collaborative effort with the participation of researchers from GCAT|Genomes for life, a strategic project of IGTP. A study published today in Nature Genetics used the vast data from the COVID-19 Host Genetics Initiative to perform the first study examining the entire genetic code specifically focused on Long COVID.
This is the main conclusion of a study that analysed data over a fifteen-year period from one million individuals in Catalonia with obesity, severe obesity, or who had undergone bariatric surgery. Crohn's disease and ulcerative colitis are the main inflammatory bowel diseases, affecting around 100,000 people in Catalonia, which today marks World IBD Day.
A study led by the Clinical Genomics Unit (UGC) has established a new cell model to advance research into NF2-related schwannomatosis (SWN-NF2), a rare genetic disease. The work, published in the journal Genes & Disease, describes the generation and characterisation of cell spheroids derived from induced pluripotent stem cells (iPSC)-a type of stem cell capable of transforming into almost any cell type-that reproduce the alterations observed in tumours associated with the disease.
Researchers from GRENBA-IGTP have identified the HDAC11 protein, an enzyme involved in cellular regulation, as a new therapeutic target to combat sarcopenia, the loss of muscle mass associated with ageing. The study shows that HDAC11 deficiency reduces muscle atrophy, preserves the muscle stem cell reservoir, promotes regeneration after injury and improves muscle function, opening the door to new strategies to support healthy ageing.
The study presents a new mouse model that more realistically mimics the disease caused by SARS-CoV-2 in humans, an essential tool for better understanding COVID.
