- Projects, Research

Full marks for the mid-term meeting of the European Project INNOVA4TB coordinated from the IGTP

At the start of Julio the mid-tem meeting of the European project "Innovation in Tuberculosis-INNOVA4TB", designed and coordinated by the Innovation in Respiratory Infections and Tuberculosis Diagnosis research group led by Dr José Dominguez and Cristina Prat took place. INNOVA4TB is a European Project focused on the diagnosis and clinical handling of tuberculosis financed by a Marie Skłodowska Curie award.

- Research

The IGTP cytometry core facility is a reference for spectral cytometry in Europe

The Cytometry core facility, headed by Dr Marco Antonio Fernández, is one of the 9 European laboratories developing multidimensional panels for spectral cytometry to study the immune response to COVID-19 with the company Cytek Biosciences. Now the IGTP is one of the reference centres in this technology, the result of work in laboratories in Holland, the United Kingdom, France, Germany and Spain.

- Research

Scientists from CEEISCAT to update HIV epidemiological surveillance protocols for Latin America and the Caribbean

The CEEISCAT, a research group led by Dr Jordi Casabona and affiliated with the IGTP, has been commissioned by the Pan American Health Organization (PAHO) to update the epidemiological surveillance protocols for HIV in Latin America and the Caribbean. The objective is to draw up a new epidemiological surveillance, and monitoring and evaluation protocol for HIV infection. With this new guide the international recommendations can be adapted to the different regions of Latin America, establishing basic concepts and clarifying the quality regulations that reinforce epidemiological surveillance.

- Research

Advance for researchers from the IGTP and ISGLobal seeking biomarkers for Chagas disease

Extracellular vesicles (EVs) that circulate in the blood of Chagas disease patients are a valuable tool to identify potential markers of therapeutic response, according to a study led by researchers at the ISGlobal, an institution supported by "la Caixa",  and the IGTP. With this strategy, the research team identified for the first time a series of proteins, including one from the parasite, that could serve to assess the response to existing or new treatments

- Research

IGTP researchers develop a new intraocular tamponade to treat retinal detachment

IGTP researchers led by Dr Xavier Valldeperas have received a Seed Grant (beca Llavor) from te Catalan Agency for Management of University and Research Grants (AGAUR) to develop a new tamponade for retinal tears in cases of retinal detachment. This innovative project will allow the design of alternative methods to those currently available, which require more follow-up care, and in some cases a second surgery or other uncomfortable treatments for the patients.

- Research

Three IGTP projects selected by the CaixaImpulse Validate Programme

The "la Caixa" Foundation has announced the 23 projects selected for the two arms of the CaixaImpulse Programme in this year's call. 20 are projects in the CaixaImpulse Validate call and three of these are led by the IGTP. These initiatives are focussed on resolving big health challenges such as: resistance to cancer treatment; complications in eye surgery and the use of microwaves to detect stent failures in implanted heart disease patients.

- Research

An international study of childhood liver cancer led by the IGTP provides new clues about its biology to improve clinical management of the disease

The Childhood Liver Oncology Research Group (C-Log) led by Carolina Armengol has published results in the context of the European project ChiLTERN which aims to improve the clinical treatment of paediatric hepatoblastoma (HB), a rare disease that mostly affects children under three. The results have been published in the Journal of Hepatology.

- Research

Funding for a project focussed on the response to immunotherapy for the treatment of colorectal cancer

This year the Fundación Mutua Madrileña has allocated 2.3 million euros for financing medical research in Spain. Four of the 21 clinical studies benefiting are projects being carried out in Catalan research centres, which will receive a total of 540,000 euros. One of these is being led by the Germans Trias I Pujol Research Institute (IGTP) and coordinated between four groups of the Programme for Predictive and Personalized Medicine of Cancer (IGTP-PMPPC).

- Research

A new gene associated with the maintenance of the protective barrier in the intestine has been identified, this is a key factor in Crohn’s disease

A multidisciplinary group of researchers from the Germans Trias i Pujol Research Institute (IGTP), the Gastroenterology Service of the Germans Trias i Pujol Hospital and the CIBER-EHD, have used transcriptomics to combine data from public databases and from Crohn's disease patient and controls. They have identified the TMIGD1 gene as having an important role in the loss of the barrier between the cells lining the small intestine and its contents. The discovery throws new light on the mechanism of Crohn's disease and opens the way for more personalized therapies.