At the IGTP TODAY
Researchers from IGTP, UPC, IrsiCaixa and CIBEREHD have developed the Cartesian Distance-Based Gene Expression (CDBGE) approach, a novel algorithm designed to identify the genes that best distinguish between different biological conditions.
The study, published in Nature Communications, evaluates ibuprofen for the first time in patients with tuberculosis as an adjunctive therapy aimed at modulating the host inflammatory response. The results did not show an improvement in the main clinical or microbiological outcomes, but they did reveal biological changes consistent with reduced inflammation, supporting further investigation of this approach in larger, controlled trials.
Researchers from BST, IGTP and Biosfer Teslab have demonstrated the potential of Nuclear Magnetic Resonance to monitor and optimise the manufacture of extracellular vesicles, one of the most promising therapeutic platforms in regenerative medicine. The findings, published in the Journal of Extracellular Vesicles, could help facilitate the development and scale-up of these therapies.
A review published in Diabetes Care analyses experimental and clinical evidence on the role of physical activity as a potential complementary strategy to promote immune regulation, preserve beta cells and reduce inflammation in type 1 diabetes.
The study, published in Nature Communications, develops a new cellular model that reproduces the progression of NF1-associated tumours and enables the identification of new therapeutic opportunities.
The GCAT team at IGTP has developed PolyGenie, a new open tool that enables researchers to explore and reuse genomic data more easily. Designed to support large-scale genetic association studies, the platform advances GCAT's commitment to FAIR data and Open Science. Its development and application to the GCAT cohort are described in NAR Genomics and Bioinformatics.
A multicentre study led by professionals from the CEEISCAT and the Institut Català d'Oncologia (ICO-IDIBELL), published in the Journal of Medical Virology, concludes that anal self-sampling for the detection and genotyping of human papillomavirus (HPV) is an accurate, feasible and well-accepted strategy among gay, bisexual and other men who have sex with men (GBMSM) and trans people in the Barcelona metropolitan area.
Roger Paredes (Germans Trias Hospital, IrsiCaixa and the Fight Infections Foundation) coordinates the international NAVIS study, launched by the WHO to advance knowledge of Andes hantavirus. The initiative also includes an advanced virology and immunology study coordinated by IrsiCaixa and IGTP Principal Investigators Julià Blanco and Nuria Izquierdo-Useros.
A study led by the IVECAT group at IGTP has identified a key mechanism regulating the anti-inflammatory function of extracellular vesicles derived from mesenchymal stromal cells. The findings, published in the Journal of Extracellular Vesicles, provide new insights into the therapeutic potential of these vesicles in inflammatory diseases and ischaemic processes.
The DIVINE cohort brings together clinical data from 5,813 patients hospitalised with COVID-19 during the first four waves of the pandemic and makes it available to the scientific community through an open, accessible and reusable resource. Published in Scientific Data, this multicentre database has already contributed to several studies and aims to support further research into the clinical progression of COVID-19, associated risk factors and the development of predictive models.
