A pilot clinical trial led by Germans Trias provides the first clinical proof of concept for ibuprofen as an adjunctive treatment for tuberculosis
The study, published in Nature Communications, evaluates ibuprofen for the first time in patients with tuberculosis as an adjunctive therapy aimed at modulating the host inflammatory response. The results did not show an improvement in the main clinical or microbiological outcomes, but they did reveal biological changes consistent with reduced inflammation, supporting further investigation of this approach in larger, controlled trials.