In 2023, the IGTP has continued to make significant strides in its mission. Here, we review the year's top news stories, reflecting the persistent drive and collaborative spirit that underpin this institution.
At the IGTP TODAY
Agarose-based method shows potential in understanding extracellular vesicles' role in cancer metastasis
A collaborative study led by researchers from IGTP has revealed the promising possibilities of using an agarose spot migration assay to examine the ability of extracellular vesicles to attract other cells in a controlled environment. The study has been recently published in the journal BMC Biology.
Two projects from IGTP funded by ”la Caixa” Foundation to transition their innovative research from the laboratory to patients
The first urine test that detects kidney fibrosis as an alternative to kidney biopsies, an initiative from the IVECAT group, and a project applying artificial intelligence to rapidly categorise stroke patients and enhance their recovery chances, from the Neurovascular Research group, are two of the fifteen projects from Catalan research centres selected within the 2023 call of the new CaixaImpulse Healthcare Innovation programme.
Mesenchymal stem cells reveal mechanisms of action in regulatory B cells independent of interleukin-10 useful for their identification and monitoring
Researchers from the REMAR-IVECAT ("Kidney Related Diseases Research" and "Innovation in VEsicles and Cells for Application in Therapy") group, from the Germans Trias i Pujol Research Institute (IGTP), identify molecular pathways in regulatory B cells that are essential for their therapeutic applications. In the article that has been recently published in Frontiers in Immunology, the use of mesenchymal stem cells has allowed distinguishing the molecules that are essential to monitoring regulatory B cells in kidney transplants.
Researchers at the Germans Trias i Pujol Research Institute (IGTP) discover new facets of the biology of extra-cellular vesicles that will advance their use in therapies. In an article published in the International Journal of Molecular Sciences they describe the importance of glycosylation for the interactions between extracellular vesicles from mesenchymal stem cells and endothelial cells.
Bioimplants with extra-cellular vesicles from stem cells can improve cardiac function after an acute myocardial heart attack
Researchers from the ICREC Group (Cardiac Insufficiency and Regeneration) in cardiovascular diseases at the Germans Trias i Pujol Research Institute (IGTP) continue to work on therapeutic technologies to repair cardiac tissue after a heart attack. In an article published in Theranostics, they present a study of extracellular vesicles from mesenchymal stem cells combined with tissue engineering as a therapy to repair the heart after a heart attack. They have carried out the study on a porcine heart attack model at the Centre for Comparative Medicine and Bioimage (CMCiB) at the IGTP.
Biomaterial scaffolds containing extracellular vesicles from stem cells to control and promote heart muscle repair after heart attack
Scientists of the ICREC group at the Germans Trias i Pujol Research institute (IGTP) continue to refine their technology for repairing cardiac tissue after a heart attack. In a paper published in Bioactive Materials they present their latest work in which they use implanted scaffolds containing no cells, but extracellular vesicles that promote the repair of myocardium damaged in a heart attack.
11 March is World Kidney Day and this year it is focussing on quality of life for people living with kidney disease. Currently 10% of the world population is affected by chronic renal disease (CRD) and more than 2 million people receive dialysis or kidney transplants worldwide. At the Germans Trias i Pujol Research Institute (IGTP) the Kidney Disease Group and the Innovation in Vesicles and Cells for Application in Therapy Group (REMAR-IVECAT) led by Francesc Borràs is working on improving diagnosis and treatments for these diseases. The group studies biomarkers for non-invasive monitoring of the conditions in patients and they are also study the application of advanced therapies. In fact they are pioneers in the use of extracellular vesicles as a therapeutic tool for kidney disease.
Members of the Kidney-affecting Diseases Research Group and the Innovation in Vesicles and Cells for Application in Therapy (REMAR-IVECAT) have recently published two studies led by Dr Francesc E. Borràs, which identify possible biomarkers of irreversible damage to transplanted kidneys; a pathology that eventually causes them to stop working. The papers have been published in the International Journal of Molecular Science and the Journal of Nephrology.
Three research groups at the IGTP have received three of the 21 grants in the 2019 call for CaixaImpulse, awarded by the "la Caixa" Foundation. The projects receiving the awards are led by Dr Katrin Beyer, Dr Francesc Borràs and Dr Alicia Martínez-Piñeiro and focus on improving the diagnostics for with Lewy body dementia; new non-invasive methods for monitoring renal dysfunction and new predictive markers for acute ischemic stroke respectively.