Immunology of Diabetes

- Research

New biomarkers to monitor and predict the remission phase (honeymoon) in children with type 1 diabetes

A study led by researchers from the Germans Trias i Pujol Research Institute (IGTP) and the Parc Tauli Hospital published in Frontiers in Immunology shows that a sample of peripheral blood can be used to identify levels of cells and molecules of the immune system that are specifically altered during the remission phase in paediatric type 1 diabetes (T1D). These can be used to monitor this phase and predict the progress of the disease.

- Research

A pilot study reveals that natural killer cells could track the progress of type 1 diabetes

The Immunology of Diabetes Group, led by Marta Vives-PI has shown that levels of 4 subtypes of natural killer (NK) cells in the blood of Type 1 Diabetes patients change through different stages of the disease. These cells have a complex role in the immune attack during T1D and have been implicated in both the destruction and protection of insulin-producing cells. This pilot study, published in Frontiers in Immunology, tracks the levels of 4 subtypes of NK cells and suggests that these cells are good candidate biomarkers for disease progression.

- Research

Artificial intelligence identifies a new drug for beta cell regeneration in type 1 diabetes

Researchers from IGTP have published an article on the identification of a drug for beta cell regeneration in type 1 diabetes. The drug is already licenced for use in people with type 2 diabetes. Using artificial intelligence researchers selected the drug from 6,605 candidates and tested it in mouse models. The drug improved hyperglycaemia and results indicate that beta cell replacement took place. More research is needed to explore its use as a new therapy for beta cell regeneration, which should be combined with an immunomodulatory strategy to reduce autoimmunity.

- Research

Talking about diabetes type 1 for World Diabetes Day

To celebrate World Diabetes Day we will literally be talking about the illness at the IGTP; several members of the Immunology of Diabetes Group, which is led by Marta Vives-Pi and concentrates on research into diabetes type 1, will be taking part in talks and discussions in scientific and public forums during the next few days.

- Research

The world’s largest non-profit funder of type 1 diabetes Research provides half a million dollars for Spanish T1D scientists

The Juvenile Diabetes Research Foundation (JDRF) is supporting a team of scientists that includes a group at the IGTP, led from the Andalusian research centre Cabimer, in their search for a cure for type 1 diabetes (T1D). Researchers in the Immunology of Diabetes Group at the IGTP are participating in the project as expert immunologists as they have wide experience of immunotherapies for T1D.