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Germans Trias i Pujol Research Institute

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News

Heart Disease

- Campus Can Ruti, Research

A team at Germans Trias treat a patient with a new bio-implant to repair heart tissue after a heart attack

The pioneering surgery that took place last May at the Germans Trias Hospital. The bio-implant, based on umbilical cord stem cells, has been developed by the Cardiovascular Disease Research Group (ICREC) at Germans Trias, led by Antoni Bayés-Genís in a research line, which they have been pursuing for 10 years. The new therapy has been developed with the collaboration of the Blood and Tissue Bank (BST) and the Institute of Bioengineering of Catalonia (IBEC); this is the first step of the application in clinical practice and the group will continue to monitor safety and the capacity of cardiac tissue to recover

- Research

A new tool that makes it possible to adapt treatment for patients with cardiogenic shock has been discovered

Cardiogenic shock is a possible complication of serious heart attack involving an associated mortality rate of approximately 50% of all cases. The combination of this new tool with existing methods renders precise and patient-specific decision-making possible. The research is being led by Dr. Antoni Bayés at Germans Trias and the Proteomics Unit of the CRG and UPF, under Dr. Eduard Sabidó

- Research

A study optimizes the probability of success for allogenic cell therapy in patients with heart failure

Researchers from the Heart Disease Research Group at the IGTP and the CIBER Cardiovascular Group both led by Dr Antoni Bayés prepare the way to optimize reparative cell therapy in heart failure patients. The study, carried out in conjunction with the Immunogenetics and Histocompatibility Laboratory and the Cell Therapy Unit of the Blood and Tissue Bank of Barcelona has studied the HLA allele and the frequency of haplotypes in a cohort of patients with heart failure as the first stage in optimizing future allogenic cell therapies for these patients.

- Research

Non-invasive stent monitoring techniques tested

Researchers have developed a new non-invasive probe to detect the presence of metallic stents and monitor their potential structural failures in models of coronary artery disease. The new probe, which has been successfully tested on a murine model, would enable the substitution of surgical controls in patients with stents with a simple outpatient procedure. The study results from a collaboration between researchers from the Germans Trias i Pujol Research Institute (IGTP), the University of Barcelona (UB) and Universitat Politècnica de Catalunya (UPC).

- Research

A study in patients with heart failure points to new prognostic markers for the disease

Researchers of the Cardiovascular Disease Group and the CIBERCV Group, led by Dr Antoni Bayés Genís, have advanced the study of prognostic markers for heart failure, a progressive disease and a public health problem of the first order. They have studied monocyte (a type of white blood cell) count and distribution in a cohort of 400 outpatients with heart failure with a view to showing their predictive value. The study has been published in PLoS One.

- Research

Telomere shortening is not a factor in the progression of cardiac insufficiency

Researchers from the Heart Disease Research Group at the Germans Trias I Pujol Research Institute (IGTP) and researchers from the Spanish Biomedical Research Network for Cardiovascular Disease (CIBERCV) have analysed  the degree of shortening of telomeres and its correlation with  progression of cardiac insufficiency (CI) over a year. The results published in Journal of Translational Medicine indicate that telomere shortening in monocytes is probably not a biomarker for the progression of CI

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