03/07/2020 - Research

A new gene associated with the maintenance of the protective barrier in the intestine has been identified, this is a key factor in Crohn’s disease

A multidisciplinary group of researchers from the Germans Trias i Pujol Research Institute (IGTP), the Gastroenterology Service of the Germans Trias i Pujol Hospital and the CIBER-EHD, have used transcriptomics to combine data from public databases and from Crohn's disease patient and controls. They have identified the TMIGD1 gene as having an important role in the loss of the barrier between the cells lining the small intestine and its contents. The discovery throws new light on the mechanism of Crohn's disease and opens the way for more personalized therapies.

15/02/2019 - Research

The Digestive Inflammatory Pathology Research Group awarded the prize for best research project at the Catalan Digestive Medicine Conference

A study by the Digestive Inflammatory Pathology Research Group at the IGTP was awarded the best basic-translational research study in the Catalan Digestive Medicine Conference 2019.  The study presented by Dr Violeta Lorén is within one of the main research lines of the group and centres on understanding, predicting and solving one of the main complications arising from therapy for patients with ulcerative colitis: the failure of glucocorticoid treatment.

29/11/2018 - Research

A novel method for combining laboratory work into a systems biology mathematical model unravels possible mechanisms for the failure of glucocorticoid therapy in ulcerative colitis

Researchers from the Digestive Inflammatory Pathology Research Group at the IGTP and the Spanish Network for Hepatic and Digestive Diseases (CIBEREHD) have identified key elements of the mechanism behind the failure of steroid treatments for ulcerative colitis in some patients. Treatment failure is one of the main obstacles in the management of this disease and the new findings could help prevent treatment failure and allow for more efficient rescue therapies when needed. The study also identifies a possible biomarker to predict which patients might suffer treatment failure.  The research was led by Dr. Eugeni Domènech and Dr. Josep Manyé, and published recently in the Journal of Crohn's and Colitis.

22/11/2018 - Institutional

Company shows solidarity with research into inflammatory bowel disease in the Christmas spirit

The construction company CBC already has its Christmas present for its staff and clients this year; the children's story "El Viaje de Crohn", a book written by Laura Marin a specialist nurse for this type of illness who works in the Digestive Inflammatory Pathology Research Group at the IGTP.  All the proceeds will go towards the group's research effort.