Digestive Inflammatory Pathology Research Group

The translational research that the Inflammatory Intestinal Disease Unit is a multidisciplinary group led from the clinical side by Dr Eugeni Domènech,  Head of the Gastroenterology & Hepatology Department and the  Inflammatory Bowel Diseases Unit at the Hospital Universitari Germans Trias i Pujol and by Dr. Josep Manyé Almero, Principal Investigator for Basic and Translational Research and CIBER-EHD Researcher.  The group is part of the CIBER-EHD Consortium (Spanish Ministry of Science) as well as part of the IBDomics Consortium for genomic research in immune-mediated inflammatory diseases of which Dr. Domènech is the Coordinator for Gastrointestinal diseases.

The Unit has carried out cutting-edge research over the last 25 years which has meant that it has reached a level of excellence in intestinal healthcare and has set a national and international benchmark for the treatment of ulcerative colitis and Crohn's disease.  In recent years the Unit established new lines of research in the field of irritable bowel syndrome and the improvement of therapeutic endoscopy. Understanding, innovating, explaining and training are important and integrated parts of our scientific task with a view to transferring our results to clinical practice. The team combines experts in different skills to ensure that research questions are tackled from the most experimental side (IGTP) to the most clinical side (HUGTP).  The research lines are based on innovative research tools, which allow us to generate new hypotheses aimed at the developmentof a more personalized medicine, better therapies and improved patient management.

Research lines

Physiopathology of intestinal inflammatory disease and therapeutic innoation

Genetic and functional characterization of phenotypes relevant to clinical practice

Post-operative recurrence (POR) of Crohn's disease

  • Determination of biomarkers for POR from omics studies
  • Investigation of the relationship between fibrotic or penetrant complications and the apparition of POR

Loss of response to cortiocosteroids in ulcerative colitis

The objective of this line of research is to use systems biology to understand corticosteroid treatment failure.  Researchers will propose new therapeutic tools to combat corticorefractionary responses.  They will determine miRNA profiles that can predict the response to therapy.

Neurogastroenterology and Research in endoscopic therapies

This line of research aims to optimize probiotic treatments for irritable bowel syndrome.   Pre-clinical studies will be carried out to improve endoscopic treatment with patches for long-term release of cytostatic or anti-inflammatory drugs.

Research projects

ONGOING PROJECTS

Papel de la aerofagia en los trastornos funcionales digestivos


Code: PI14/01703
Investigator principal: Jordi Serra                                                                                               
Start Date: 01/01/2015
End Date: 31/12/2018

Los trastornos funcionales digestivos afectan al 30 % de la población general, son la causa más frecuente de consulta en
gastroenterología, y suponen una gran carga económica tanto por gastos sanitarios directos como indirectos. Los síntomas
relacionados con gas son los más frecuentemente referidos por los pacientes. Actualmente conocemos que el gas producido
durante la fermentación bacteriana juega un papel importante en el desarrollo de los síntomas, pero desconocemos el papel
del gas atmosférico, que es el gas mayoritario en el tubo digestivo. El objetivo de este proyecto es determinar el papel que
juega el gas proveniente de la ingesta en el desarrollo de síntomas abdominales en los pacientes con trastornos funcionales
digestivos, y desarrollar estrategias terapéuticas específicas. Se diseñarán de forma consecutiva protocolos independientes 1.
Se realizará un estudio dosis-respuesta, comparando en grupos de sujetos sanos los efectos de diferentes volúmenes de gas
infundido en el estómago sobre las respuestas motoras y sensoriales. 2. Una vez conocidas las respuestas normales al gas gástrico, se estudiarán grupos de pacientes con trastornos funcionales específicos, en los que se valorarán las repuestas al gas gástrico en estudios paralelos comparados con una cohorte de sujetos sanos. 3. Se  realizarán estudios terapéuticos mediante diseño cruzado, randomizado y controlado con placebo. En todos los estudios se realizará una infusión intragástrica de gas y se medirá el gas eructado, mediante manometria-impedanciometria de esófago y bolsa oral de recogida, transito gastro-rectal de gas mediante una cánula rectal, percepción de síntomas mediante un cuestionario y distensión abdominal.

More information

Contact

Eugeni Domènech Morral and Josep Manyé Almero

Dr Domènech (+34) 93 497 89 09, Dr Manyé (+34) 93 497 86 95

edomenech.germanstrias(ELIMINAR)@gencat.cat

josep.manye(ELIMINAR)@ciberehd.org