Research

Publicaciones científicas

  • Planas-Ballve, A, Rios, J, Ispierto, L, Gea, M, Grau, L, Jimenez, M, Caceres, C, Martinez, S, Beyer, K, Alvarez, R, Pastor, P and Vilas, D.

    Key motor and non-motor features in early dementia with Lewy bodies

    Frontiers in Neurology 16: 1555175-1555175

    [doi:10.3389/fneur.2025.1555175]

  • Wang, CY, Yang, CR, Western, D, Ali, M, Wang, YY, Phuah, CL, Budde, J, Wang, LH, Gorijala, P, Timsina, J, Ruiz, A, Pastor, P, Fernandez, MV, Perrin, R, Panyard, DJ, Engelman, CD, Deming, Y, Boada, M, Cano, A, Garcia-Gonzalez, P, Graff-Radford, NR, Mori, H, Lee, JH, Perrin, RJ, Ibanez, L, Sung, YJ, Cruchaga, C, Dominantly Inherited Alzheimer Network DIAN and Alzheimers Dis Neuroimaging Initiative ADNI.

    Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits

    Nature Genetics 56(12): 2685-2695

    [doi:10.1038/s41588-024-01973-7]

  • Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M, Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ and Cruchaga C.

    Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.

    Nature Genetics 56(12): 2672-2684

    [doi:10.1038/s41588-024-01972-8]

  • Agúndez, JAG, Macías, Y, Alonso-Navarro, H, García-Martín, E, Alvarez, I, Pastor, P, Benito-León, J, López-Alburquerque, T and Jiménez-Jiménez, FJ.

    Association Between Common Variants in the LAG3/CD4 Genes and Risk for Essential Tremor

    International Journal of Molecular Sciences 25(24):

    [doi:10.3390/ijms252413403]

  • García-García, C, López-Sobrino, T, Sanz-Girgas, E, Cueto, MR, Aboal, J, Pastor, P, Buera, I, Sionis, A, Andrea, R, Rodríguez-López, J, Sánchez-Salado, JC, Tomas, C, Bañeras, J, Ariza, A, Lupón, J, Bayés-Genís, A and Rueda, F.

    Cardiogenic shock mortality according to Aetiology in a Mediterranean cohort: Results from the Shock-CAT study

    ESC Heart Failure 12(2): 1336-1345

    [doi:10.1002/ehf2.15148]

  • Shen, YY, Timsina, J, Heo, G, Beric, A, Ali, M, Wang, CY, Yang, CR, Wang, YY, Western, D, Liu, MH, Gorijala, P, Budde, J, Do, A, Liu, HY, Gordon, B, Llibre-Guerra, JJ, Joseph-Mathurin, N, Perrin, RJ, Maschi, D, Wyss-Coray, T, Pastor, P, Renton, AE, Surace, EI, Johnson, ECB, Levey, AI, Alvarez, I, Levin, J, Ringman, JM, Allegri, RF, Seyfried, N, Day, GS, Wu, QS, Fernandez, MV, Tarawneh, R, McDade, E, Morris, JC, Bateman, RJ, Goate, A, Ibanez, L, Sung, YJ and Cruchaga, C.

    CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease

    Cell 187(22):

    [doi:10.1016/j.cell.2024.08.049]

  • Planas-Ballvé, A, Rios, J, Gea, M, Rabaneda-Lombarte, N, Ispierto, L, Grau, L, Jiménez, M, Cáceres, C, Martínez, S, Beyer, K, Alvarez, R, Pastor, P and Vilas, D.

    Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies

    ALZHEIMERS RESEARCH & THERAPY 16(1): 227-227

    [doi:10.1186/s13195-024-01590-w]

  • Sosero, YL, Bandres-Ciga, S, Ferwerda, B, Tocino, MTP, Belloso, DR, Gómez-Garre, P, Faouzi, J, Taba, P, Pavelka, L, Marques, TM, Gomes, CPC, Kolodkin, A, May, P, Milanowski, LM, Wszolek, ZK, Uitti, RJ, Heutink, P, van Hilten, JJ, Simon, DK, Eberly, S, Alvarez, I, Krohn, L, Yu, E, Freeman, K, Rudakou, U, Ruskey, JA, Asayesh, F, Menendez-Gonzalez, M, Pastor, P, Ross, OA, Krueger, R, Corvol, JC, Koks, S, Mir, P, De Bie, RMA, Iwaki, H and Gan-Or, Z.

    Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia

    Movement Disorders 39(10): 1773-1783

    [doi:10.1002/mds.29960]

  • Marsh, TW, Western, D, Timsina, J, Gorijala, P, Yang, C, Pastor, P, Liu, M, Morris, JC, Bateman, RJ, Schindler, SE, Sung, YJ and Cruchaga, C.

    A genetic and proteomic comparison of key AD biomarkers across tissues

    ALZHEIMERS & DEMENTIA 20(9): 6423-6440

    [doi:10.1002/alz.14139]

  • Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L, Farrell, K, Mclean, C, Molina-Porcel, L, Rajput, A, De Deyn, PP, Le Bastard, N, Gearing, M, Kaat, LD, Van Swieten, JC, Dopper, E, Ghetti, BF, Newell, KL, Troakes, C, de Yebenes, JG, Rabano-Gutierrez, A, Meller, T, Oertel, WH, Respondek, G, Stamelou, M, Arzberger, T, Roeber, S, Müller, U, Hopfner, F, Pastor, P, Brice, A, Durr, A, Le Ber, I, Beach, TG, Serrano, GE, Hazrati, LN, Litvan, I, Rademakers, R, Ross, OA, Galasko, D, Boxer, AL, Miller, BL, Seeley, WW, Van Deerlin, VM, Lee, EB, White, CL III, Morris, H, de Silva, R, Crary, JF, Goate, AM, Friedman, JS, Leung, YY, Coppola, G, Naj, AC, Wang, LS, Dalgard, C, Dickson, DW, Höglinger, GU, Schellenberg, GD, Geschwind, DH and Lee, WP.

    Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

    Molecular Neurodegeneration 19(1):

    [doi:10.1186/s13024-024-00747-3]

  • Staer, K, Iranzo, A, Stokholm, MG, Hvingelby, VS, Danielsen, EH, Ostergaard, K, Serradell, M, Otto, M, Svendsen, KB, Garrido, A, Vilas, D, Santamaria, J, Moller, A, Gaig, C, Brooks, DJ, Borghammer, P, Tolosa, E and Pavese, N.

    Microglial Activation and Progression of Nigrostriatal Dysfunction in Isolated REM Sleep Behavior Disorder

    Movement Disorders 39(8): 1323-1328

    [doi:10.1002/mds.29767]

  • Pérez-Oliveira, S, Castilla-Silgado, J, Painous, C, Aldecoa, I, Menéndez-González , M, Blázquez-Estrada, M, Corte, D, Tomás-Zapico, C, Compta, Y, Muñoz, E, Lladó, A, Balasa, M, Aragonès, G, García-González,P, Rosende-Roca, M, Boada, M, Ruíz, A, Pastor, P, De la Casa-Fages, B, Rabano, A, Sánchez-Valle, R, Molina-Porcel, L and Alvarez, V.

    Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights

    Brain Pathology 34(4):

    [doi:10.1111/bpa.13250]

  • Menon, PJ, Sambin, S, Criniere-Boizet, B, Courtin, T, Tesson, C, Casse, F, Ferrien, M, Mariani, LL, Carvalho, S, Lejeune, FX, Rebbah, S, Martet, G, Houot, M, Lanore, A, Mangone, G, Roze, E, Vidailhet, M, Aasly, J, Or, ZG, Yu, ER, Dauvilliers, Y, Zimprich, A, Tomantschger, V, Pirker, W, Alvarez, I, Pastor, P, Di Fonzo, A, Bhatia, KP, Magrinelli, F, Houlden, H, Real, R, Quattrone, A, Limousin, P, Korlipara, P, Foltynie, T, Grosset, D, Williams, N, Narendra, D, Lin, HP, Jovanovic, C, Svetel, M, Lynch, T, Gallagher, A, Vandenberghe, W, Gasser, T, Brockmann, K, Morris, HR, Borsche, M, Klein, C, Corti, O, Brice, A, Lesage, S and Corvol, JC.

    Genotype-phenotype correlation in PRKN-associated Parkinson's disease

    npj Parkinsons Disease 10(1):

    [doi:10.1038/s41531-024-00677-3]

  • Wang, LH, Nykaenen, NP, Western, D, Gorijala, P, Timsina, J, Li, FH, Wang, ZH, Ali, M, Yang, CR, Liu, MH, Brock, W, Marquie, M, Boada, M, Alvarez, I, Aguilar, M, Pastor, P, Ruiz, A, Puerta, R, Orellana, A, Rutledge, J, Oh, H, Greicius, MD, Le Guen, Y, Perrin, RJ, Wyss-Coray, T, Jefferson, A, Hohman, TJ, Graff-Radford, N, Mori, H, Goate, A, Levin, J, Sung, YJ and Cruchaga, C.

    Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease

    Molecular Neurodegeneration 19(1):

    [doi:10.1186/s13024-023-00687-4]

  • García-Alberca, JM, de Rojas, I, Sanchez-Mejias, E, Garrido-Martín, D, Gonzalez-Palma, L, Jimenez, S, Pino-Angeles, A, Cruz-Gamero, JM, Mendoza, S, Alarcón-Martín, E, Muñoz-Castro, C, Real, LM, Tenao, JJ, Polvillo, R, Govantes, F, Lopez, A, Royo-Aguado, JL, Navarro, V, Gonzalez, I, Ruiz, M, Reyes-Engel, A, Gris, E, Bravo, MJ, Lopez-Gutierrez, L, Mejias-Ortega, M, De la Guía, P, de la Rica, ML, Ocejo, O, Torrecilla, J, Zafra, C, Nieto, MD, Urbano, C, Jiménez-Sánchez, R, Pareja, N, Luque, M, García-Peralta, M, Carrillejo, R, Furniet, MD, Rueda, L, Sánchez-Fernández, A, Mancilla, T, Peña, I, García-Casares, N, Moreno-Grau, S, Hernández, I, Montrreal, L, Quintela, I, Gónzalez-Pérez, A, Calero, M, Franco-Macías, E, Macías, J, Menéndez-González, M, Frank-García, A, Vilas, RH, Diez-Fairen, M, Lage, C, García-Madrona, S, García-González, P, Valero, S, Sotolongo-Grau, O, Pérez-Cordón, A, Rabano, A, Pastor, AA, Pastor, AB, Espinosa, A, Corma-Gómezn, A, Montes, AM, Sanabria, A, Rodríguez, CM, Buiza-Rueda, D, Rodriguez-Rodriguez, E, Ortega, G, Alvarez, I, Allende, IR, Pineda, JA, Rosende-Roca, M, Sánchez-Arjona, MB, Fernández-Fuertes, M, Alegret, M, Roberto, N, del Ser, T, Garcia-Ribas, G, Sánchez-Juan, P, Pastor, P, Piñol-Ripoll, G, Bullido, MJ, Alvarez, V, Mir, P, Medina, M, Marquié, M, Sáez, ME, Carracedo, A, Laplana, M, Tomas-Gallardo, L, Orellana, A, Tarraga, L, Boada, M, Palazon, JF, Vitorica, J, Ruiz, A, Guigo, R, Gutierrez, A and Royo, JL.

    An Insertion Within SIRPß1 Shows a Dual Effect Over Alzheimer's Disease Cognitive Decline Altering the Microglial Response

    JOURNAL OF ALZHEIMERS DISEASE 98(2): 601-618

    [doi:10.3233/JAD-231150]

  • Kim, JJ, Vitale, D, Otani, DV, Lian, MM, Heilbron, K, Aslibekyan, S, Auton, A, Babalola, E, Bell, RK, Bielenberg, J, Bryc, K, Bullis, E, Cannon, P, Coker, D, Partida, GC, Dhamija, D, Das, S, Elson, SL, Eriksson, N, Filshtein, T, Fitch, A, Fletez-Brant, K, Fontanillas, P, Freyman, W, Granka, JM, Hernandez, A, Hicks, B, Hinds, DA, Jewett, EM, Jiang, YX, Kukar, K, Kwong, A, Lin, KH, Llamas, BA, Lowe, M, McCreight, JC, McIntyre, MH, Micheletti, SJ, Moreno, ME, Nandakumar, P, Nguyen, DT, Noblin, ES, O'Connell, J, Petrakovitz, AA, Poznik, GD, Reynoso, A, Schloetter, M, Schumacher, M, Shastri, AJ, Shelton, JF, Shi, JCZ, Shringarpure, S, Su, QJ, Tat, SA, Tchakoute, CT, Tran, V, Tung, JY, Wang, X, Wang, W, Weldon, CH, Wilton, P, Wong, CD, Iwaki, H, Lake, J, Solsberg, CW, Leonard, H, Makarious, MB, Tan, EK, Singleton, AB, Bandres-Ciga, S, Noyce, AJ, Gatto, EM, Kauffman, M, Khachatryan, S, Tavadyan, Z, Shepherd, CE, Hunter, J, Kumar, K, Ellis, M, Renteria, ME, Koks, S, Zimprich, A, Schumacher-Schuh, AF, Rieder, C, Awad, PS, Tumas, V, Camargos, S, Fon, EA, Monchi, O, Fon, T, Galleguillos, BP, Miranda, M, Bustamante, ML, Olguin, P, Chana, P, Tang, BS, Shang, HF, Guo, JF, Chan, P, Luo, W, Arboleda, G, Orozc, J, del Rio, MJ, Hernandez, A, Salama, M, Kamel, WA, Zewde, YZ, Brice, A, Corvol, JC, Westenberger, A, Illarionova, A, Mollenhauer, B, Klein, C, Vollstedt, EJ, Hopfner, F, Höglinger, G, Madoev, H, Trinh, J, Junker, J, Lohmann, K, Lange, LM, Sharma, M, Groppa, S, Gasser, T, Fang, ZH, Akpalu, A, Xiromerisiou, G, Hadjigorgiou, G, Dagklis, I, Tarnanas, I, Stefanis, L, Stamelou, M, Dadiotis, E, Medina, A, Chan, GHF, Ip, N, Cheung, NYF, Chan, P, Zhou, XP, Kishore, A, Divya, KP, Pal, P, Kukkle, PL, Rajan, R, Borgohain, R, Salari, M, Quattrone, A, Valente, EM, Parnetti, L, Avenali, M, Schirinzi, T, Funayama, M, Hattori, N, Shiraishi, T, Karimova, A, Kaishibayeva, G, Shambetova, C, Krueger, R, Tan, AH, Ahmad-Annuar, A, Norlinah, MI, Murad, NAA, Azmin, S, Lim, SY, Mohamed, W, Tay, YW, Martinez-Ramirez, D, Rodriguez-Violante, M, Reyes-Perez, P, Tserensodnom, B, Ojha, R, Anderson, TJ, Pitcher, TL, Sanyaolu, A, Okubadejo, N, Ojo, O, Aasly, JO, Pihlstrom, L, Tan, M, Ur-Rehman, S, Veliz-Otani, D, Cornejo-Olivas, M, Doquenia, ML, Rosales, R, Vinuela, A, Iakovenko, E, Al Mubarak, B, Umair, M, Amod, F, Carr, J, Bardien, S, Jeon, B, Kim, YJ, Cubo, E, Alvarez, I, Hoenicka, J, Beyer, K, Perinan, MT, Pastor, P, El-Sadig, S, Brolin, K, Zweier, C, Tinkhauser, G, Krack, P, Lin, CH, Wu, HC, Kung, PJ, Wu, RM, Wu, YH, Amouri, R, Ben Sassi, S, Basak, AN, Genc, G, Çakmak, ÖÖ, Ertan, S, Martinez-Carrasco, A, Schrag, A, Schapira, A, Carroll, C, Bale, C, Grosset, D, Stafford, EJ, Houlden, H, Morris, HR, Hardy, J, Mok, KY, Rizig, M, Wood, N, Williams, N, Okunoye, O, Lewis, PA, Kaiyrzhanov, R, Weil, R, Love, S, Stott, S, Jasaityte, S, Dey, S, Obese, V, Espay, A, O'Grady, A, Sobering, AK, Siddiqi, B, Casey, B, Fiske, B, Jonas, C, Cruchaga, C, Pantazis, CB, Comart, C, Wegel, C, Hall, D, Hernandez, D, Shiamim, E, Riley, E, Faghri, F, Serrano, GE, Chen, HL, Mata, IF, Sarmiento, IJK, Williamson, J, Jankovic, J, Shulman, J, Solle, JC, Murphy, K, Nuytemans, K, Kieburtz, K, Markopoulou, K, Marek, K, Levine, KS, Chahine, LM, Ibanez, L, Screven, L, Ruffrage, L, Shulman, L, Marsili, L, Kuhl, M, Dean, M, Koretsky, M, Puckelwartz, MJ, Inca-Martinez, M, Louie, N, Mencacci, NE, Albin, R, Alcalay, R, Walker, R, Chowdhury, S, Dumanis, S, Lubbe, S, Xie, T, Foroud, T, Beach, T, Sherer, T, Song, YJ, Nguyen, D, Nguyen, T, Atadzhanov, M, Blauwendraat, C, Nalls, MA, Foo, JN and Mata, I.

    Multi-ancestry genome-wide association meta-analysis of Parkinson's disease

    Nature Genetics 56(1):

    [doi:10.1038/s41588-023-01584-8]

  • Ariz, M, Martínez, M, Alvarez, I, Fernández-Seara, MA, Castellanos, G, Pastor, P, Pastor, MA and de Solórzano, CO.

    Automatic Segmentation and Quantification of Nigrosome-1 Neuromelanin and Iron in MRI: A Candidate Biomarker for Parkinson's Disease

    Journal of Magnetic Resonance Imaging 60(2): 534-547

    [doi:10.1002/jmri.29073]

  • Onieva, Ana, Martin, Joan, R Cuesta-Aguirre, Daniel, Planells, Violeta, Coronado-Zamora, Marta, Beyer, Katrin, Vega, Tomas, Lozano, Jose Eugenio, Santos, Cristina and Aluja, Maria Pilar.

    Complete mitochondrial DNA profile in stroke: A geographical matched case-control study in Spanish population

    Mitochondrion 73: 51-61

    [doi:10.1016/j.mito.2023.10.001]

  • Guillén, N, Contador, J, Buongiorno, M, Alvarez, I, Culell, N, Alcolea, D, Lleó, A, Fortea, J, Piñol-Ripoll, G, Carnes-Vendrell, A, Ispierto, ML, Vilas, D, Puig-Pijoan, A, Fernández-Lebrero, A, Balasa, M, Sánchez-Valle, R and Lladó, A.

    Agreement of cerebrospinal fluid biomarkers and amyloid-PET in a multicenter study

    European Archives of Psychiatry and Clinical Neuroscience 275(1): 257-266

    [doi:10.1007/s00406-023-01701-y]

  • Arnaldo, L, Urbizu, A, Serradell, M, Gaig, C, Anillo, A, Gea, M, Vilas, D, Ispierto, L, Muñoz-Lopetegi, A, Mayà, G, Pastor, P, Alvarez, R, Santamaria, J, Iranzo, A and Beyer, K.

    Peripheral a-synuclein isoforms are potential biomarkers for diagnosis and prognosis of isolated REM sleep behavior disorder

    PARKINSONISM & RELATED DISORDERS 115:

    [doi:10.1016/j.parkreldis.2023.105832]

  • Phillips, B, Western, D, Wang, LH, Timsina, J, Sun, YC, Gorijala, P, Yang, CR, Do, A, Nykanen, NP, Alvarez, I, Aguilar, M, Pastor, P, Morris, JC, Schindler, SE, Fagan, AM, Puerta, R, Garcia-Gonzalez, P, de Rojas, I, Marquie, M, Boada, M, Ruiz, A, Perlmutter, JS, Ibanez, L, Perrin, RJ, Sung, YJ and Cruchaga, C.

    Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease

    npj Parkinsons Disease 9(1):

    [doi:10.1038/s41531-023-00555-4]

  • Santos-García, D, Fonticoba, TD, Bartolomé, CC, Painceiras, MJF, González, JMP, Miro, CM, Jesús, S, Aguilar, M, Pastor, P, Planellas, L, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Vara, JH, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Mayordomo, VG, Nogueira, V, Puente, V, García-Soto, JD, Borrué, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Padilla, FC, Castrillo, JCM, Alonso, PS, Losada, MGA, Ariztegui, NL, Gastón, I, Kulisevsky, J, Estrada, MB, Seijo, M, Martínez, JR, Valero, C, Kurtis, M, de Fábregues, O, Ardura, JG, Redondo, RA, Ordás, C, Diaz, LMLL, McAfee, D, Martinez-Martin, P and Mir, P.

    Risk of Cognitive Impairment in Patients With Parkinson's Disease With Visual Hallucinations and Subjective Cognitive Complaints

    Journal of Clinical Neurology 19(4): 344-357

    [doi:10.3988/jcn.2022.0186]

  • Gonzalez, MC, Tovar-Rios, DA, Alves, G, Dalen, I, Williams-Gray, CH, Camacho, M, Forsgren, L, Bäckström, D, Lawson, RA, Macleod, AD, Counsell, CE, Paquet, C, DeLena, C, D'Antonio, F, Pilotto, A, Padovani, A, Blanc, F, Falup-Pecurariu, C, Lewis, SJG, Rejdak, K, Papuc, E, Hort, J, Nedelska, Z, O'Brien, J, Bonanni, L, Marquié, M, Boada, M, Pytel, V, Abdelnour, C, Alcolea, D, Beyer, K, Tysnes, OB, Aarsland, D and Maple-Grodem, J.

    Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

    Movement Disorders Clinical Practice 10(6): 980-986

    [doi:10.1002/mdc3.13752]

  • Luo, J, Thomassen, JQ, Bellenguez, C, Grenier-Boley, B, de Rojas, I, Castillo, A, Parveen, K, Küçükali, F, Nicolas, A, Peters, O, Schneider, A, Dichgans, M, Rujescu, D, Scherbaum, N, Jürgen, D, Riedel-Heller, S, Hausner, L, Porcel, LM, Düzel, E, Grimmer, T, Wiltfang, J, Heilmann-Heimbach, S, Moebus, S, Tegos, T, Scarmeas, N, Clarimon, J, Moreno, F, Pérez-Tur, J, Bullido, MJ, Pastor, P, Sánchez-Valle, R, Alvarez, V, Boada, M, García-González, P, Puerta, R, Mir, P, Real, LM, Piñol-Ripoll, G, García-Alberca, JM, Royo, JL, Rodriguez-Rodriguez, E, Soininen, H, Kuulasmaa, T, de Mendonça, A, Mehrabian, S, Hort, J, Vyhnalek, M, van der Lee, S, Graff, C, Papenberg, G, Giedraitis, V, Boland, A, Bacq-Daian, D, Deleuze, JF, Nicolas, G, Dufouil, C, Pasquier, F, Hanon, O, Debette, S, Grünblatt, E, Popp, J, Benussi, L, Galimberti, D, Arosio, B, Mecocci, P, Solfrizzi, V, Parnetti, L, Squassina, A, Tremolizzo, L, Borroni, B, Nacmias, B, Sorbi, S, Caffarra, P, Seripa, D, Rainero, I, Daniele, A, Masullo, C, Spalletta, G, Williams, J, Amouyel, P, Jessen, F, Kehoe, P, Magda, T, Rossi, G, Sánchez-Juan, P, Sleegers, K, Ingelsson, M, Andreassen, OA, Hiltunen, M, Van Duijn, C, Sims, R, van der Flier, W, Ruiz, A, Ramirez, A, Lambert, JC and Frikke-Schmidt, R.

    Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

    JAMA Network Open 6(5):

    [doi:10.1001/jamanetworkopen.2023.13734]

  • Vilas, D, Rubio, S, Gea, M, Rios, J, Ispierto, L, Hernandez-Perez, M, Pare, M, Millan, M and Dorado, L.

    Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study

    Journal of Headache and Pain 24(1):

    [doi:10.1186/s10194-023-01576-3]

  • Martinez, M, Ariz, M, Alvarez, I, Castellanos, G, Aguilar, M, Hernandez-Vara, J, Caballol, N, Garrido, A, Bayes, A, Vilas, D, Marti, MJ, Pastor, P, de Solorzano, CO and Pastor, MA.

    Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson's disease

    npj Parkinsons Disease 9(1):

    [doi:10.1038/s41531-023-00503-2]

  • Sugier, PE, Lucotte, EA, Domenighetti, C, Law, MH, Iles, MM, Brown, K, Amos, C, McKay, JD, Hung, RJ, Karimi, M, Bacq-Daian, D, Boland-Augé, A, Olaso, R, Deleuze, JF, Lesueur, F, Ostroumova, E, Kesminiene, A, de Vathaire, F, Guénel, P, Sreelatha, AAK, Schulte, C, Grover, S, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, AE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschländer, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Nakayama, A, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Kolber, P, van de Warrenburg, BPC, Bloem, BR, Aasly, J, Toft, M, Pihlstrom, L, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, N, Ran, C, Belin, AC, Puschmann, A, Rödström, EY, Clarke, CE, Morrison, KE, Tan, M, Krainc, D, Burbulla, LF, Farrer, MJ, Kruger, R, Gasser, T, Sharma, M, Truong, T and Elbaz, A.

    Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

    Movement Disorders 38(4): 604-615

    [doi:10.1002/mds.29337]

  • Viana-Tejedor, A, Andrea-Riba, R, Scardino, C, Ariza-Solé, A, Bañeras, J, García-García, C, Mena, MJ, Vila, M, Martínez-Sellés, M, Pastor, G, Acuña, JG, Loma-Osorio, P, Rubira, JCG, Pérez, PJ, Pastor, P, Ferrera, C, Noriega, FJ, Macías, NP, Fernández-Ortiz, A, Pérez-Villacastín, J and Ensayo Clin COUPE.

    Coronary angiography in patients without ST-segment elevation following out-of- hospital cardiac arrest. COUPE clinical trial

    REVISTA ESPANOLA DE CARDIOLOGIA 76(2): 94-102

    [doi:10.1016/j.recesp.2022.05.004]

  • Urbizu, Aintzane, Arnaldo, Laura and Beyer, Katrin.

    Obtaining miRNA from Saliva-Comparison of Sampling and Purification Methods

    International Journal of Molecular Sciences 24(3):

    [doi:10.3390/ijms24032386]

  • García-González, P, de Rojas, I, Moreno-Grau, S, Montrreal, L, Puerta, R, Alarcón-Martín, E, Quintela, I, Orellana, A, Andrade, V, Adami, PVM, Heilmann-Heimbach, S, Gomez-Garre, P, Periñán, MT, Alvarez, I, Diez-Fairen, M, Llaves, RN, Olive, RC, Garcia-Ribas, G, Menéndez-González, M, Martínez, C, Aguilar, M, Buongiorno, M, Franco-Macías, E, Saez, ME, Cano, A, Bullido, MJ, Real, LM, Rodríguez-Rodríguez, E, Royo, JL, Alvarez, V, Pastor, P, Piñol-Ripoll, G, Mir, P, Lara, MC, Padilla, MM, Sánchez-Juan, P, Carracedo, A, Valero, S, Hernandez, I, Tàrraga, L, Ramirez, A, Boada, M and Ruiz, A.

    Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men

    International Journal of Molecular Sciences 24(2):

    [doi:10.3390/ijms24020898]

  • Jimenez-Jimenez, FJ, Gomez-Tabales, J, Alonso-Navarro, H, Rodriguez, C, Turpin-Fenoll, L, Millan-Pascual, J, Alvarez, I, Pastor, P, Calleja, M, Garcia-Ruiz, R, Navarro-Munoz, S, Recio-Bermejo, M, Plaza-Nieto, JF, Garcia-Albea, E, Garcia-Martin, E and Agundez, JAG.

    LAG3/CD4 Genes Variants and the Risk for Restless Legs Syndrome

    International Journal of Molecular Sciences 23(23):

    [doi:10.3390/ijms232314795]

  • Devos, D, Labreuche, J, Rascol, O, Corvol, JC, Duhamel, A, Delannoy, PG, Poewe, W, Compta, Y, Pavese, N, Ruzicka, E, Dusek, P, Post, B, Bloem, BR, Berg, D, Maetzler, W, Otto, M, Habert, MO, Lehericy, S, Ferreira, J, Dodel, R, Tranchant, C, Eusebio, A, Thobois, S, Marques, AR, Meissner, WG, Ory-Magne, F, Walter, U, de Bie, RMA, Gago, M, Vilas, D, Kulisevsky, J, Januario, C, Coelho, MVS, Behnke, S, Worth, P, Seppi, K, Ouk, T, Potey, C, Leclercq, C, Viard, R, Kuchcinski, G, Lopes, R, Pruvo, JP, Pigny, P, Garcon, G, Simonin, O, Carpentier, J, Rolland, AS, Nyholm, D, Scherfler, C, Mangin, JF, Chupin, M, Bordet, R, Dexter, DT, Fradette, C, Spino, M, Tricta, F, Ayton, S, Bush, AI, Devedjian, JC, Duce, JA, Cabantchik, I, Defebvre, L, Deplanque, D and Moreau, C.

    Trial of Deferiprone in Parkinson's Disease

    New England Journal of Medicine 387(22): 2045-2055

    [doi:10.1056/NEJMoa2209254]

  • Jansen, RE, van der Lee, SJ, Gomez-Fonseca, D, de Rojas, I, Dalmasso, MC, Grenier-Boley, B, Zettergren, A, Mishra, A, Ali, M, Andrade, V, Bellenguez, C, Kleineidam, L, Kucukali, F, Sung, YJ, Tesi, N, Vromen, EM, Wightman, DP, Alcolea, D, Alegret, M, Alvarez, I, Amouyel, P, Athanasiu, L, Bahrami, S, Bailly, H, Belbin, O, Bergh, S, Bertram, L, Biessels, GJ, Blennow, K, Blesa, R, Boada, M, Boland, A, Buerger, K, Carracedo, A, Cervera-Carles, L, Chene, G, Claassen, JAHR, Debette, S, Deleuze, JF, de Deyn, PP, Diehl-Schmid, J, Djurovic, S, Dols-Icardo, O, Dufouil, C, Duron, E, Duzel, E, Fladby, T, Fortea, J, Frolich, L, Garcia-Gonzalez, P, Garcia-Martinez, M, Giegling, I, Goldhardt, O, Gobom, J, Grimmer, T, Haapasalo, A, Hampel, H, Hanon, O, Hausner, L, Heilmann-Heimbach, S, Helisalmi, S, Heneka, MT, Hernandez, I, Herukka, SK, Holstege, H, Jarholm, J, Kern, S, Knapskog, AB, Koivisto, AM, Kornhuber, J, Kuulasmaa, T, Lage, C, Laske, C, Leinonen, V, Lewczuk, P, Lleo, A, de Munain, AL, Lopez-Garcia, S, Maier, W, Marquie, M, Mol, MO, Montrreal, L, Moreno, F, Moreno-Grau, S, Nicolas, G, Nothen, MM, Orellana, A, Palhaugen, L, Papma, JM, Pasquier, F, Perneczky, R, Peters, O, Pijnenburg, YAL, Popp, J, Posthuma, D, Pozueta, A, Priller, J, Puerta, R, Quintela, I, Ramakers, I, Rodriguez-Rodriguez, E, Rujescu, D, Saltvedt, I, Sanchez-Juan, P, Scheltens, P, Scherbaum, N, Schmid, M, Schneider, A, Selbaek, G, Selnes, P, Shadrin, A, Skoog, I, Soininen, H, Tarraga, L, Teipel, S, Tijms, B, Tsolaki, M, Van Broeckhoven, C, Van Dongen, J, van Swieten, JC, Vandenberghe, R, Vidal, JS, Visser, PJ, Vogelgsang, J, Waern, M, Wagner, M, Wiltfang, J, Wittens, MMJ, Zetterberg, H, Zulaica, M, van Duijn, CM, Bjerke, M, Engelborghs, S, Jessen, F, Teunissen, CE, Pastor, P, Hiltunen, M, Ingelsson, M, Andreassen, OA, Clarimon, J, Sleegers, K, Ruiz, A, Ramirez, A, Cruchaga, C, Lambert, JC and van der Flier, W.

    Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

    Acta Neuropathologica 144(5): 821-842

    [doi:10.1007/s00401-022-02454-z]

  • Perez-Oliveira, S, Alvarez, I, Rosas, I, Menendez-Gonzalez, M, Blazquez-Estrada, M, Aguilar, M, Corte, D, Buongiorno, M, Molina-Porcel, L, Aldecoa, I, Marti, MJ, Sanchez-Juan, P, Infante, J, Gonzalez-Aramburu, I, Garcia-Gonzalez, P, Rosende-Roca, M, Boada, M, Ruiz, A, Perinan, MT, Macias-Garcia, D, Munoz-Delgado, L, Gomez-Garre, P, Mir, P, Clarimon, J, Lleo, A, Alcolea, D, De la Casa-Fages, B, Duarte, I, Alvarez, V and Pastor, P.

    Intermediate and Expanded HTT Alleles and the Risk for alpha-Synucleinopathies

    Movement Disorders 37(9): 1841-1849

    [doi:10.1002/mds.29153]

  • Corral-Juan, M, Casquero, P, Giraldo-Restrepo, N, Laurie, S, Martinez-Pineiro, A, Mateo-Montero, RC, Ispierto, L, Vilas, D, Tolosa, E, Volpini, V, Alvarez-Ramo, R, Sanchez, I and Matilla-Duenas, A.

    New spinocerebellar ataxia subtype caused by SAMD9L mutation triggering mitochondrial dysregulation (SCA49)

    Brain Communications 4(2):

    [doi:10.1093/braincomms/fcac030]

  • Gonzalez-Casacuberta, I, Vilas, D, Pont-Sunyer, C, Tobias, E, Canto-Santos, J, Valls-Roca, L, Garcia-Garcia, FJ, Garrabou, G, Grau-Junyent, JM, Marti, MJ, Cardellach, F and Moren, C.

    Neuronal induction and bioenergetics characterization of human forearm adipose stem cells from Parkinson's disease patients and healthy controls

    PLoS ONE 17(3):

    [doi:10.1371/journal.pone.0265256]

  • Fernandez-Ramos, JA, De la Torre-Aguilar, MJ, Quintans, B, Perez-Navero, JL, Beyer, K and Lopez-Laso, E.

    Genetic landscape of Segawa disease in Spain. Long-term treatment outcomes

    PARKINSONISM & RELATED DISORDERS 94: 67-78

    [doi:10.1016/j.parkreldis.2021.11.014]

  • Planas-Ballve, A and Vilas, D.

    Cognitive Impairment in Genetic Parkinson's Disease

    PARKINSONS DISEASE 2021: 8610285-8610285

    [doi:10.1155/2021/8610285]

  • Ferrer-Raventos, P and Beyer, K.

    Alternative platelet activation pathways and their role in neurodegenerative diseases

    Neurobiology of Disease 159: 105512-105512

    [doi:10.1016/j.nbd.2021.105512]

  • Gamez-Valero, A, Campdelacreu, J, Vilas, D, Ispierto, L, Gascon-Bayarri, J, Rene, R, Alvarez, R, Armengol, MP, Borras, FE and Beyer, K.

    Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer's Disease

    Biomedicines 9(9):

    [doi:10.3390/biomedicines9091272]

  • Fernandez-Espejo, E, de Fonseca, FR, Suarez, J, Tolosa, E, Vilas, D, Aldecoa, I, Berenguer, J and Damas-Hermoso, F.

    Native alpha-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-alpha-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson's Disease

    Antioxidants 10(5):

    [doi:10.3390/antiox10050715]

  • Marsal-Garcia, L, Urbizu, A, Arnaldo, L, Campdelacreu, J, Vilas, D, Ispierto, L, Gascon-Bayarri, J, Rene, R, Alvarez, R and Beyer, K.

    Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease

    International Journal of Molecular Sciences 22(2):

    [doi:10.3390/ijms22020725]

  • Crespo-Cuevas, AM, Canento, T, Hernandez-Perez, M, Caceres, C, Gonzalez, A, Ispierto, L, Mataro, M, Vilas, D, Planas-Ballve, A, Martin, L, Munoz-Ortiz, L, Arenillas, F, Via, M, Castanon, M, Millan, M, Dorado, L and Lopez-Cancio, E.

    The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) study: Subclinical cervico-cerebral stenosis and middle cerebral artery pulsatility index as predictors of long-term incident cognitive impairment

    Atherosclerosis 312: 104-109

    [doi:10.1016/j.atherosclerosis.2020.08.025]

  • Urbizu A and Beyer K.

    Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

    International Journal of Molecular Sciences 21(13):

    [doi:10.3390/ijms21134718]

  • Forcen, S, Cuevas, AMC, Aldecoa, I, Ramos, O, Ispierto, L, Alvarez, R and Vilas, D.

    Overlapping neuropathological findings in an asymptomatic SPAST gene mutation carrier

    Clinical Neuropathology 39(4): 162-166

    [doi:10.5414/NP301239]

  • Crespo-Cuevas, AM, Lopez-Cancio, E, Caceres, C, Gonzalez, A, Ispierto, L, Hernandez-Perez, M, Mataro, M, Planas, A, Canento, T, Martin, L, Arenillas, JF, Alvarez, R and Vilas, D.

    Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment

    JOURNAL OF ALZHEIMERS DISEASE 73(2): 741-749

    [doi:10.3233/JAD-190949]

  • Vilas, D, Tolosa, E, Quintana, M, Pont-Sunyer, C, Santos, M, Casellas, A, Valldeoriola, F, Compta, Y, Marti, MJ and Mullol, J.

    Olfaction in LRRK2 Linked Parkinson's Disease: Is It Different from Idiopathic Parkinson's Disease?

    JOURNAL OF PARKINSONS DISEASE 10(3): 951-958

    [doi:10.3233/JPD-201972]

  • Gamez-Valero, A, Campdelacreu, J, Vilas, D, Ispierto, L, Rene, R, Alvarez, R, Armengol, MP, Borras, FE and Beyer, K.

    Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies

    Translational Neurodegeneration 8(1): 31-31

    [doi:10.1186/s40035-019-0169-5]

  • Gamez-Valero, A, Campdelacreu, J, Rene, R, Beyer, K and Borras, FE.

    Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients

    Scientific Reports 9(1): 13282-13282

    [doi:10.1038/s41598-019-49668-y]

  • Agalliu, I, Ortega, RA, San Luciano, M, Mirelman, A, Pont-Sunyer, C, Brockmann, K, Vilas, D, Tolosa, E, Berg, D, Waro, B, Glickman, A, Raymond, D, Inzelberg, R, Ruiz-Martinez, J, Mondragon, E, Friedman, E, Hassin-Baer, S, Alcalay, RN, Mejia-Santana, H, Aasly, J, Foroud, T, Marder, K, Giladi, N, Bressman, S and Saunders-Pullman, R.

    Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls

    Movement Disorders 34(9): 1392-1398

    [doi:10.1002/mds.27807]

  • Perez-Roca, L, Prada-Dacasa, P, Segu-Verges, C, Gamez-Valero, A, Serrano-Munoz, MA, Santos, C and Beyer, K.

    Glucocerebrosidase regulators SCARB2 and TFEB are up-regulated in Lewy body disease brain

    Neuroscience Letters 706: 164-168

    [doi:10.1016/j.neulet.2019.05.034]

  • Garrido, A, Fairfoul, G, Tolosa, ES, Marti, MJ, Green, A, Compta, Y, Valldeoriola, F, Munoz, E, Fernandez, M, Alvarez, R, Vilas, D, Ispierto, L, De Fabregues, O, Hernandez-Vara, J, Puente, V, Calopa, M, Jauma, S, Campdelacreu, J, Bayes, A, Avila, A, Caballol, N, Aguilar, M and Casquero, P.

    alpha-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease

    Annals of Clinical and Translational Neurology 6(6): 1024-1032

    [doi:10.1002/acn3.772]

  • Dorado, L, Rubio-Guerra, S, Valls-Carbo, A, Ispierto, L, Hernandez-Perez, M, Pare, M and Vilas, D.

    Hypoechogenicity of the raphe nuclei as a biomarker of migraine: A case-control study, review, and meta-analysis

    Journal of Neuroimaging :

    [doi:10.1111/jon.13070]