Molecular and Translational Pathology
Pedro L. Fernández Ruiz
Our group is mostly dedicated to research on biomarkers and molecular mechanisms underlying the development and progression of malignant neoplasms and we aim to provide translational knowledge to advance the diagnosis, prognosis and prediction of a variety of human cancers. For this purpose, we combine both morphological (light and ultrastructural microscopy) and advanced molecular tools including next generations sequencing (NGS), in situ hybridization and immunohistochemistry; these integrated with bioinformatics tools such as digital pathology, provide a multidisciplinary approach to cancer research. We also have a special interest, and long and productive research tradition in non-neoplastic conditions, including neurodegenerative diseases including dementias and nephropathology amongst others.
Our group of Molecular and Translational Pathology has been repeatedly recognized as a Consolidated Research Group (2017SGR639) by the Agency for Management of University and Research Grants (AGAUR) of the Government of Catalonia.

Research lines
(Publications for the Group)
1: Breast and genitourinary neoplasms
Pedro L Fernández, M. Carmen Gómez-Plaza, Eva Castellá, Cristina Carrato
2: Lymphoid and mesenchymal neoplasms
Gustavo Tapia, José L. Mate, Caterina Fumagalli
3: Respiratory tract, and head & neck neoplasms
José L. Mate, Alba Hernández, Ariadna Quer
4: Digestive and hepatobiliary tract neoplasms
Raquel López, Alba Hernández, Laura Hernández, Caterina Fumagalli
5: Nervous and endocrine systems neoplasms, and neurodegenerative disorders
Cristina Carrato, Aurelio Ariza, Katrin Beyer
6: Skin neoplasms
Ariadna Quer, Caterina Fumagalli, Paula Rodriguez
7: Nefropathology and fetal pathology
Dolores López Álvarez, Paula Rodriguez, Marta Ávila
8: Molecular Pathology
A Muñoz, Carolina Sanz
9. Paleopathology*
Pedro L Fernández
*See: Ordi J, Alonso PL, Zulueta J, Esteban J, Velasco M, Mas E, Campo E, Fernández PL. The severe gout of Holy Roman Emperor Charles V. New Engl J Med 2006; 355:516-20
Members of the Group
Head of Service
Pedro L Fernández Ruiz(ELIMINAR)
Head of Section
José L. Mate Sanz(ELIMINAR)
Medical and Research Staff
Gustavo Tapia Melendo(ELIMINAR)
Cristina Carrato Moñino(ELIMINAR)
Eva Castellá Fernández(ELIMINAR)
M. Carmen Gómez Plaza(ELIMINAR)
Alba Hernández Gallego(ELIMINAR)
Ariadna Quer Pi-Sunyer(ELIMINAR)
Raquel López Martos (ELIMINAR)
Laura Hernández León (ELIMINAR)
Paula Rodriguez Martínez (ELIMINAR)
Dolores López Álvarez (ELIMINAR)
Marta Ávila Terzi (ELIMINAR)
Katrin Beyer (ELIMINAR)
Ana Mª Muñoz Marmol (ELIMINAR)
Carolina Sanz Monte(ELIMINAR)
Research Projects
Ongoing Projects
Molecular characterization of genomics and phenotypical patterns related to resistance to neoadjuvant therapy in triple negative and Her2 positive breast carcinomas
Code: PI19/01371
Principlal Investigator: Pedro L Fernández
Start Date: 01/01/2020
End Date: 31/12/2022
Comprehensive molecular and microspectroscopic profiling of breast carcinomas and their resistance to neoadjuvant treatment
Code: La Marató de TV3 567/2019
Principlal Investigator: Pedro L Fernández
Start Date: 01/01/2020
End Date: 31/12/2022
Disclosing the transcriptome of HIV-DLBCL for targeted therapy
Code: Becas Gilead a la investigación biomédica
Principlal Investigator: Jose Tomas Navarro
Start Date: 01/01/2020
End Date: 31/12/2021
Análisis epigenómico integral del linfoma plasmablástico: identificación de características epigenéticas para mejorar el diagnóstico y pronóstico de los pacientes
Code: PI19/01588
Principlal Investigator: Jose Tomas Navarro
Start Date: 01/01/2020
End Date: 31/12/2022
Caracterización molecular del glioblastoma. Correlación clínico-radiológica, genómica, transcriptómica e inmunohistoquímica
Code: PI18/01062
Principlal Investigator: Carmen Balaña
Start Date: 01/01/2019
End Date: 31/12/2021
Definición del perfil de expresión génica en biopsias renales de pacientes con obesidad mórbida y estadios precoces de glomerulopatía de la obesidad
Code: PI18/01951
Principlal Investigator: Maruja Navarro Díaz
Start Date: 01/01/2019
End Date: 31/12/2021
Estudio de las lesiones tuberculosas obtenidas mediante cirugía torácia: en búsqueda de los biomarcadores que mejor correlacionan con la patología, la clínica y la epidermiología
Code: PI16/01511
Principlal Investigator: Cristina Vilaplana Massaguer
Start Date: 01/01/2017
End Date: 31/12/2019
News
The IGTP presents CARE Translational Program in Cancer Research
CARE, the Translational Program in Cancer Research is the first transversal program promoted by the Germans Trias i Pujol Research Institute (IGTP), and it aims to become a bridge for researchers in the field of cancer who want to bring basic and clinical research together, so that the knowledge and the tools generated in the laboratory can benefit the patient.
The Barcelona Medical Photonics Network: united to improve the health and well-being of society
As the research institute of the Germans Trias i Pujol Hospital, the IGTP is one of 8 health research institutes that has joined the ICFO to consolidate a state-of-the-art bench to bedside Barcelona Photonics Technology Network. The Medical Photonics Network of Barcelona was presented on 18 February, it aims to promote the research and development activities in photonics being carried out in the Barcelona area by formalizing the long-running relationship between the ICFO and its biomedical and clinical partners.
More information
Contact
Pedro L. Fernández Ruiz
(+34) 93 497 8853