Molecular and Translational Pathology

Pedro L. Fernández Ruiz

Our group is mostly dedicated to research on biomarkers and molecular mechanisms underlying the development and progression of malignant neoplasms and we aim to provide translational knowledge to advance the diagnosis, prognosis and prediction of a variety of human cancers. For this purpose, we combine both morphological (light and ultrastructural microscopy) and advanced molecular tools including next generations sequencing (NGS), in situ hybridization and immunohistochemistry; these integrated with bioinformatics tools such as digital pathology, provide a multidisciplinary approach to cancer research. We also have a special interest, and long and productive research tradition in non-neoplastic conditions, including neurodegenerative diseases including dementias and nephropathology amongst others.

Our group of Molecular and Translational Pathology has been repeatedly recognized as a Consolidated Research Group (2017SGR639) by the Agency for Management of University and Research Grants (AGAUR) of the Government of Catalonia.

Research lines

(Publications for the Group)

1: Breast and genitourinary neoplasms

Pedro L Fernández, M. Carmen  Gómez-Plaza, Eva Castellá, Cristina Carrato

2: Lymphoid and mesenchymal  neoplasms

Gustavo Tapia, José L. Mate, Caterina Fumagalli

3: Respiratory tract, and head & neck neoplasms

José L. Mate, Alba Hernández,  Ariadna Quer

4: Digestive and hepatobiliary tract neoplasms

Raquel López, Alba Hernández, Laura Hernández, Caterina Fumagalli

5: Nervous and endocrine systems  neoplasms, and neurodegenerative disorders

Cristina Carrato, Aurelio Ariza, Katrin Beyer

6: Skin neoplasms

Ariadna Quer, Caterina Fumagalli, Paula Rodriguez

7: Nefropathology and fetal pathology

Dolores López Álvarez, Paula Rodriguez, Marta Ávila

8: Molecular Pathology

A Muñoz, Carolina Sanz

9. Paleopathology*

Pedro L Fernández

*See: Ordi J, Alonso PL, Zulueta J, Esteban J, Velasco M, Mas E, Campo E, Fernández PL. The severe gout of Holy Roman Emperor Charles V. New Engl J Med 2006; 355:516-20 

Members of the Group

Head of Service
Pedro L Fernández Ruiz(ELIMINAR) 

Head of Section
José L. Mate Sanz(ELIMINAR)

Medical and Research Staff

Gustavo Tapia Melendo(ELIMINAR)
Cristina Carrato Moñino(ELIMINAR)
Eva Castellá Fernández(ELIMINAR)
M. Carmen  Gómez Plaza(ELIMINAR)
Alba Hernández Gallego(ELIMINAR)
Ariadna Quer Pi-Sunyer(ELIMINAR)
Raquel López Martos (ELIMINAR)
Laura Hernández León (ELIMINAR)
Paula Rodriguez Martínez (ELIMINAR) 
Dolores López Álvarez (ELIMINAR)
Marta Ávila Terzi (ELIMINAR) 
Katrin Beyer (ELIMINAR) 
Ana Mª Muñoz  Marmol (ELIMINAR) 
Carolina Sanz Monte(ELIMINAR) 

Research Projects

Ongoing Projects

Molecular characterization of genomics and phenotypical patterns related to resistance to neoadjuvant therapy in triple negative and Her2 positive breast carcinomas

Code: PI19/01371
Principlal Investigator: Pedro L Fernández  
Start Date: 01/01/2020
End Date: 31/12/2022

Comprehensive molecular and microspectroscopic profiling of breast carcinomas and their resistance to neoadjuvant treatment

Code: La Marató de TV3 567/2019
Principlal Investigator: Pedro L Fernández  
Start Date: 01/01/2020
End Date: 31/12/2022

Disclosing the transcriptome of HIV-DLBCL for targeted therapy 

Code: Becas Gilead a la investigación biomédica
Principlal Investigator: Jose Tomas Navarro  
Start Date: 01/01/2020
End Date: 31/12/2021  

Análisis epigenómico integral del linfoma plasmablástico: identificación de características epigenéticas para mejorar el diagnóstico y pronóstico de los pacientes   

Code: PI19/01588
Principlal Investigator: Jose Tomas Navarro 
Start Date: 01/01/2020
End Date: 31/12/2022


Caracterización molecular del glioblastoma. Correlación clínico-radiológica, genómica, transcriptómica e inmunohistoquímica 

Code: PI18/01062
Principlal Investigator:  Carmen Balaña  
Start Date: 01/01/2019
End Date: 31/12/2021

Definición del perfil de expresión génica en biopsias renales de pacientes con obesidad mórbida y estadios precoces de glomerulopatía de la obesidad

Code: PI18/01951
Principlal Investigator: Maruja Navarro Díaz  
Start Date: 01/01/2019
End Date: 31/12/2021

Estudio de las lesiones tuberculosas obtenidas mediante cirugía torácia: en búsqueda de los biomarcadores que mejor correlacionan con la patología, la clínica y la epidermiología

Code: PI16/01511
Principlal Investigator: Cristina Vilaplana Massaguer  
Start Date: 01/01/2017
End Date: 31/12/2019


- Campus Can Ruti

The IGTP presents CARE Translational Program in Cancer Research

CARE, the Translational Program in Cancer Research is the first transversal program promoted by the Germans Trias i Pujol Research Institute (IGTP), and it aims to become a bridge for researchers in the field of cancer who want to bring basic and clinical research together, so that the knowledge and the tools generated in the laboratory can benefit the patient.

- Research

The Barcelona Medical Photonics Network: united to improve the health and well-being of society

As the research institute of the Germans Trias i Pujol Hospital, the IGTP is one of 8 health research institutes that has joined the ICFO to consolidate a state-of-the-art bench to bedside Barcelona Photonics Technology Network. The Medical Photonics Network of Barcelona was presented on 18 February, it aims to promote the research and development activities in photonics being carried out in the Barcelona area by formalizing the long-running relationship between the ICFO and its biomedical and clinical partners.

More information


Pedro L. Fernández Ruiz

(+34) 93 497 8853