Research

Publicacions científiques

  • Cives-Losada, C, Macias, RIR, Lozano, E, Zanatto, L, Sancho-Bru, P, Martinez-Chantar, ML, Avila, MA, Armengol, C, Cairo, S, Marin, JJG and Briz, O.

    Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition

    Acta Pharmacologica Sinica :

    [doi:10.1038/s41401-026-01791-z]

  • Campana, JP, Cifone, T, Salazar, EG, Rossi, G, Mentz, R, Vaccaro, C, Daneri, MD, Uriburu, JCP, Cillo, M, Ruiz, H, Estefania, D, Rotholtz, N, Harriott, CB, Bun, M, Campagno, F, Carrie, A, Santillan, M, Avellaneda, N, Chwat, C, Alexandre, F, Rosato, G, Valli, D, Duarte, MR, Alesandrini, A, Perriello, J, Miranda, N, Leiro, F, Bigerna, M, Bianchi, R, Gondolesi, G, Gonzalez, M, Moreno, L, Bozzetti, M, Lucas, M, Sotelo, JM, Leone, AI, Jacinto, P, Canelas, A, Farina, P, Lumi, CM, Avila, KC, Caruso, E, Muñoz, JP, Gesto, NM, Marasca, M, Espino, J, Trama, M, Cedermas, M, Arbios, P, Zanoni, G, Minoldo, J, Pereira, GV, Giordanino, JM, Sosa, LMS, Pierotti, A, Gorreta, F, Danielli, E, Rodriguez, GM, Canesin, CS, Bertani, D, Minati, W, Carrozzo, E, Molina, R, Robales, C, Francisco, A, Hendl, MP, Marcucci, G, Lorenzi, L, Marchetti, N, Gigli, J, Posner, F, Schor, M, Balmaceda, R, Galvarini, M, Agnella, Y, Barranco, MM, Paredes, F, Velásquez, S, Girardini, J and Sesma, J.

    Early-onset colorectal cancer in Argentina: a multicenter surgical analysis of incidence, stage, and metastatic patterns

    Lancet Regional Health-Americas 56:

    [doi:10.1016/j.lana.2026.101415]

  • Martínez-Pérez, LA, Latasa, MU, Uriarte, I, López-Pascual, A, Elurbide, J, Strnad, P, Frankova, S, Sticova, E, Fabian, O, Arechederra, M, Santamaria, E, Argemi, J, Sangro, B, Foglia, B, Parola, M, Gutiérrez-Angulo, M, Cairo, S, Bataller, R, Sancho-Bru, P, Martinez-Chantar, ML, Marin, JJG, Castaneda, A, Armengol, C, Berasain, C, Fernandez-Barrena, MG and Avila, MA.

    Trefoil Factor-3 Is a Hypoxia-Triggered Pro-Tumorigenic Factor in Hepatoblastoma

    Liver International 46(4):

    [doi:10.1111/liv.70592]

  • Khoubai, FZ, Calovoulos, A, Guillorit, H, Carrillo-Reixach, J, del Rio-Alvarez, A, Klein, P, Coma, MS, Avignon, C, Rousseau, B, Charrot, LM, Fedou, S, Dupuy, JW, Royo, L, Domingo-Sàbat, M, Thézé, N, Siegfried, G, Khatib, AM, Cairo, S, Indersie, E, Jain, BP, Trézéguet, V, Gontier, E, Lamoureux, F, Guettier, C, Mussini, C, Hagedorn, M, Armengol, C and Grosset, CF.

    EZH2 is a key prognostic marker and therapeutic target in aggressive and proliferative hepatoblastoma

    Molecular Cancer 25(1):

    [doi:10.1186/s12943-025-02474-9]

  • Balaseviciute, U, Huguet-Pradell, J, Abril-Fornaguera, J, Gris-Oliver, A, Rialdi, A, Fernández-Martínez, E, Montironi, C, Del Pozo, V, Houghton, P, Zanatto, L, Mesropian, A, Keraite, I, Thung, S, Armengol, C, Sancho-Bru, P, Guccione, E, Pinyol, R and Llovet, JM.

    Effective therapeutic targeting of CTNNB1-mutant hepatoblastoma with WNTinib

    Molecular Oncology :

    [doi:10.1002/1878-0261.70168]

  • Zapata-Pavas, LE, Serrano-Macia, M, Rodrigo, MAM, Barrenechea-Barrenechea, JA, Peña-SanFelix, P, del Río-Alvarez, A, Gil-Pitarch, C, Rejano-Gordillo, CM, Goikoetxea-Usandizaga, N, González-Recio, I, Michalkova, H, Mercado-Gomez, M, Lachiondo-Ortega, S, Castañeda, A, Asensio, M, Murti, A, Lelou, E, Nogueiras, R, Mayor, U, Heger, Z, Sancho-Bru, P, Delgado, TC, Calvisi, DF, Xirodimas, DP, Wang, BC, Marin, JJG, Fernandez-Barrena, MG, Armengol, C, Avila, M and Martínez-Chantar, ML.

    NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1-NEDD8 pathway

    Hepatology :

    [doi:10.1097/HEP.0000000000001614]

  • Cai, ZX, Boys, EL, Noor, Z, Aref, AT, Xavier, D, Lucas, N, Williams, SG, Koh, JMS, Poulos, RC, Wu, YX, Dausmann, M, Mackenzie, KL, Aguilar-Mahecha, A, Armengol, C, Barranco, MM, Basik, M, Bowman, ED, Clifton-Bligh, R, Connolly, EA, Cooper, WA, Dalal, B, Defazio, A, Filipits, M, Flynn, PJ, Graham, JD, George, J, Gill, AJ, Gnant, M, Habib, R, Harris, CC, Harvey, K, Horvath, LG, Jackson, C, Kohonen-Corish, MRJ, Lim, E, Liu, J, Long, GV, Lord, RV, Mann, GJ, Mccaughan, GW, Morgan, L, Murphy, L, Nagabushan, S, Nagrial, A, Navinés, J, Panizza, BJ, Samra, JS, Scolyer, RA, Souglakos, J, Swarbrick, A, Thomas, D, Balleine, RL, Hains, PG, Robinson, PJ, Zhong, Q and Reddel, RR.

    Federated Deep Learning Enables Cancer Subtyping by Proteomics

    Cancer Discovery 15(9): 1803-1818

    [doi:10.1158/2159-8290.CD-24-1488]

  • Ravoni, A, Mastrostefano, E, Kappler, R, Armengol, C, Castiglione, F and Nardini, C.

    Mimicking cancer therapy in an agent-based model: The case of hepatoblastoma

    Computer Methods and Programs in Biomedicine 269: 108917-108917

    [doi:10.1016/j.cmpb.2025.108917]

  • Xie, TK, Sorenson, JC, Spector, LG, Pankratz, N, Huang, RS, Hiyama, E, Poynter, JN, Tomlinson, GE, Armengol, C, Kappler, R, Scheurer, ME, Roman, E, Castellano, A, Grotzer, MA, Ziegler, DS, Basu, S, Marcotte, EL and Yang, TZ.

    Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 34(8): 1405-1414

    [doi:10.1158/1055-9965.EPI-24-1553]

  • Cives-Losada, C, Asensio, M, Briz, O, Chinchilla-Tábora, LM, Barranco, MM, del Río-Alvarez, A, Martinez-Chantar, ML, Avila, MA, Cairo, S, Armengol, C, Marin, JJG and Macias, RIR.

    Relevance of transportome among the mechanisms of chemoresistance in hepatoblastoma

    Biochemical Pharmacology 237: 116914-116914

    [doi:10.1016/j.bcp.2025.116914]

  • Fonseca, KL, Lozano, JJ, Despuig, A, Habgood-Coote, D, Sidorova, J, Aznar, D, Arias, L, del Río-Alvarez, A, Carrillo-Reixach, J, Goff, A, Wildner, LM, Gogishvili, S, Nikolaishvili, K, Shubladze, N, Avaliani, Z, Tapia, G, Rodríguez-Martínez, P, Cardona, PJ, Martinón-Torres, F, Salas, A, Gómez-Carballa, A, Armengol, C, Waddell, SJ, Kaforou, M, O'Garra, A, Vashakidze, S and Vilaplana, C.

    Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications

    Nature Communications 16(1): 5028-5028

    [doi:10.1038/s41467-025-60255-w]

  • Iborra, I, Bartoli, R, Ardèvol, A, Torner, M, Bermúdez-Ramos, M, Bargalló, A, Masnou, H and Morillas, RM.

    Xyloglucan protects the intestinal barrier and reduces bacterial translocation in experimental cirrhosis - A promising non-antibiotic strategy

    Revista Espanola de Enfermedades Digestivas 117(9): 490-496

    [doi:10.17235/reed.2025.11236/2025]

  • Whitby, A, Pabla, P, Shastri, B, Amugi, L, Del Río-alvarez, A, Kim, DH, Royo, L, Armengol, C and Dandapani, M.

    Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)

    Cancers 15(21):

    [doi:10.3390/cancers15215182]

  • Claveria-Cabello, A, Herranz, JM, Latasa, MU, Arechederra, M, Uriarte, I, Pineda-Lucena, A, Prosper, F, Berraondo, P, Alonso, C, Sangro, B, Marin, JJG, Martinez-Chantar, ML, Ciordia, S, Corrales, FJ, Francalanci, P, Alaggio, R, Zucman-Rossi, J, Indersie, E, Cairo, S, Domingo-Sàbat, M, Zanatto, L, Sancho-Bru, P, Armengol, C, Berasain, C, Fernandez-Barrena, MG and Avila, MA.

    Identification and experimental validation of druggable epigenetic targets in hepatoblastoma

    Journal of Hepatology 79(4): 537-538

    [doi:10.1016/j.jhep.2023.05.031]

  • Failli, M, Demir, S, Del Río-Alvarez, A, Carrillo-Reixach, J, Royo, L, Domingo-Sàbat, M, Childs, M, Maibach, R, Alaggio, R, Czauderna, P, Morland, B, Branchereau, S, Cairo, S, Kappler, R, Armengol, C and di Bernardo, D.

    Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response

    Hepatology 80(1): 55-68

    [doi:10.1097/HEP.0000000000000601]

  • Fang, J, Singh, S, Cheng, CD, Natarajan, S, Sheppard, H, Abu-Zaid, A, Durbin, AD, Lee, HW, Wu, Q, Steele, J, Connelly, JP, Jin, HJ, Chen, WN, Fan, YP, Pruett-Miller, SM, Rehg, JE, Koo, SC, Santiago, T, Emmons, J, Cairo, S, Wang, RN, Glazer, ES, Murphy, AJ, Chen, TS, Davidoff, AM, Armengol, C, Easton, J, Chen, X and Yang, J.

    Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

    Nature Communications 14(1):

    [doi:10.1038/s41467-023-39717-6]

  • Sanchez-Moral, L, Paul, T, Martori, C, Font-Diaz, J, Sanjurjo, L, Aran, G, Tellez, E, Blanco, J, Carrillo, J, Ito, M, Tuttolomondo, M, Ditzel, HJ, Fumagalli, C, Tapia, G, Sidorova, J, Masnou, H, Fernandez-Sanmartin, MA, Lozano, JJ, Vilaplana, C, Rodriguez-Cortes, A, Armengol, C, Valledor, AF, Kremer, L and Sarriasa, MR.

    Macrophage CD5L is a target for cancer immunotherapy

    EBioMedicine 91:

    [doi:10.1016/j.ebiom.2023.104555]

  • Abril-Fornaguera, J, Torrens, L, Andreu-Oller, C, Carrillo-Reixach, J, Rialdi, A, Balaseviciute, U, Pinyol, R, Montironi, C, Haber, PK, Del Rfo-Alvarez, A, Domingo-Sabat, M, Royo, L, Akers, NK, Willoughby, CE, Peix, J, Torres-Martin, M, Puigvehi, M, Cairo, S, Childs, M, Maibach, R, Alaggio, R, Czauderna, P, Morland, B, Losic, B, Mazzaferro, V, Guccione, E, Sia, D, Armengol, C and Llovet, JM.

    Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma

    Molecular Cancer Therapeutics 22(4): 485-498

    [doi:10.1158/1535-7163.MCT-22-0335]

  • Li, Q, Demir, S, Del Rio-Alvarez, A, Maxwell, R, Wagner, A, Carrillo-Reixach, J, Armengol, C, Vokuhl, C, Haberle, B, von Schweinitz, D, Schmid, I, Cairo, S and Kappler, R.

    Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma

    Cancers 14(17):

    [doi:10.3390/cancers14174196]

  • Corujo, D, Malinverni, R, Carrillo-Reixach, J, Meers, O, Garcia-Jaraquemada, A, Le Pannerer, MM, Valero, V, Perez, A, Del Rio-Alvarez, A, Royo, L, Perez-Gonzalez, B, Raurell, H, Acemel, RD, Santos-Pereira, JM, Garrido-Pontnou, M, Gomez-Skarmeta, JL, Pasquali, L, Manye, J, Armengol, C and Buschbeck, M.

    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines

    Cell Reports 39(12):

    [doi:10.1016/j.celrep.2022.110988]

  • Mosca, N, Khoubai, FZ, Fedou, S, Carrillo-Reixach, J, Caruso, S, Del Rio-Alvarez, A, Dubois, E, Avignon, C, Dugot-Senant, N, Guettier, C, Mussini, C, Zucman-Rossi, J, Armengol, C, Thiebaud, P, Veschambre, P and Grosset, CF.

    LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways

    Liver Cancer 11(2): 126-140

    [doi:10.1159/000521595]

  • Farres, J, Ruiz, JL, Mas, JM, Arias, L, Sarrias, MR, Armengol, C, Cardona, PJ, Munoz-Moreno, JA, Vilaplana, M, Arranz, B, Usall, J, Serrano-Blanco, A and Vilaplana, C.

    Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic

    BMJ Open 11(11):

    [doi:10.1136/bmjopen-2021-052140]

  • Del Rio, M, Lopez-Cabrera, P, Malagon-Lopez, P, Del Cano-Aldonza, MC, Castello, JR and Provencio, M.

    Effect of intravenous lidocaine on ischemia-reperfusion injury in DIEP microsurgical breast reconstruction. A prospective double-blind randomized controlled clinical trial

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY 74(4): 809-818

    [doi:10.1016/j.bjps.2020.10.018]

  • Cairo, S, Armengol, C, Maibach, R, Haberle, B, Becker, K, Carrillo-Reixach, J, Guettier, C, Vokuhl, C, Schmid, I, Buendia, MA, Branchereau, S, von Schweinitz, D and Kappler, R.

    A combined clinical and biological risk classification improves prediction of outcome in hepatoblastoma patients

    European Journal of Cancer 141: 30-39

    [doi:10.1016/j.ejca.2020.09.026]

  • Carrillo-Reixach, J, Torrens, L, Simon-Coma, M, Royo, L, Domingo-Sabat, M, Abril-Fornaguera, J, Akers, N, Sala, M, Ragull, S, Arnal, M, Villalmanzo, N, Cairo, S, Villanueva, A, Kappler, R, Garrido, M, Guerra, L, Sabado, C, Guillen, G, Mallo, M, Pineyro, D, Vazquez-Vitali, M, Kuchuk, O, Mateos, ME, Ramirez, G, Santamaria, ML, Mozo, Y, Soriano, A, Grotzer, M, Branchereau, S, de Andoin, NG, Lopez-Ibor, B, Lopez-Almaraz, R, Salinas, JA, Torres, B, Hernandez, F, Uriz, JJ, Fabre, M, Blanco, J, Paris, C, Bajciova, V, Laureys, G, Masnou, H, Clos, A, Belendez, C, Guettier, C, Sumoy, L, Planas, R, Jorda, M, Nonell, L, Czauderna, P, Morland, B, Sia, D, Losic, B, Buendia, MA, Sarrias, MR, Llovet, JM and Armengol, C.

    Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

    Journal of Hepatology 73(2): 328-341

    [doi:10.1016/j.jhep.2020.03.025]

  • Aguilar-Bravo, B, Rodrigo-Torres, D, Arino, S, Coll, M, Pose, E, Blaya, D, Graupera, I, Perea, L, Vallverdu, J, Rubio-Tomas, T, Dubuquoy, L, Armengol, C, Lo Nigro, A, Starkel, P, Mathurin, P, Bataller, R, Caballeria, J, Lozano, JJ, Gines, P and Sancho-Bru, P.

    Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis

    Hepatology 69(5): 2180-2195

    [doi:10.1002/hep.30472]

  • Barcena, C, Aran, G, Perea, L, Sanjurjo, L, Tellez, E, Oncins, A, Masnou, H, Serra, I, Garcia-Gallo, M, Kremer, L, Sala, M, Armengol, C, Sancho-Bru, P and Sarrias, MR.

    CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content

    EBioMedicine 43: 513-524

    [doi:10.1016/j.ebiom.2019.04.052]