Translational Research in Hepatic Diseases

Rosa Maria Morillas

Ramon Bartolí

We are a multidisciplinary group led from the clinical side by Dr Rosa Mª Morillas,  Head of the Hepatology Department at the Hospital Universitari Germans Trias i Pujol and by Dr. Ramon Bartolí, Principal Investigator for Basic and Translational Research and CIBER researcher.

The group focuses on clinical and translational research on chronic hepatitis, nonalcoholic fatty liver disease, cirrhosis and complications of portal hypertension (ascites, hemorrhage due to portal hypertension, hepatic encephalopathy, spontaneous bacterial peritonitis, infections) and hepatocellular carcinoma. We also have experience in the development of different experimental models of liver disease (cirrhotic rat model with ascites -carbon tetrachloride-, model of hepatic encephalopathy -cirrhosis + portal vein ligation-,  model of secondary biliary cirrhosis due to ligation of the common bile duct and steatohepatitis model with different degrees of fibrosis (metabolic model + carbon tetrachloride). Also, we have developed an endoscopic platform able to release drugs and active agents in colonic tract and studding its applicability in different liver diseases.  Our group also work together with other groups or lead collaborative projects within societies like the SCD, AEEH, EASL and CIBER. 

Participation in Research of the Carlos III Health Institute. Researcher of the work group: Prevention and treatment of the complications of chronic liver disease, from the GTiPUH, which is part of the National Network of Research in Hepatology and Gastroenterology (RNIHG) and researcher at the Center for Biomedical Research in Networks in Hepatic Diseases and Digestive (CIBERehd) 2006 / Area 1: Portal hypertension and mechanisms of transition to cirrhosis.

Research lines

Group Members

Clinical Trials

The group has very clinical and translational focus and a long-standing experience in clinical trials in cirrhosis, portal hypertension,  chronic hepatitis, alcoholic hepatitis,  non-alcoholic steatohepatitis, primary biliary cholangitis and liver  fibrosis led by pharma industries but also in those promoted by scientific societies.

Projects

Screening for liver fibrosis - population-based study across European countries (LIVERSCREEN)

Code: H2020- SC1-BHC-30-2019- ID847989
Principal Investigator: Rosa Maria Morillas                                                                               
Start Date: 2020
End Date: 2024


Project title: Investigación en Gastroenterología y Hepatología

Central PI: Helena Masnou
Start date: 2020
End date: 2022    
Funding agency: Norgine