A novel method for combining laboratory work into a systems biology mathematical model unravels possible mechanisms for the failure of glucocorticoid therapy in ulcerative colitis
Researchers from the Digestive Inflammatory Pathology Research Group at the IGTP and the Spanish Network for Hepatic and Digestive Diseases (CIBEREHD) have identified key elements of the mechanism behind the failure of steroid treatments for ulcerative colitis in some patients. Treatment failure is one of the main obstacles in the management of this disease and the new findings could help prevent treatment failure and allow for more efficient rescue therapies when needed. The study also identifies a possible biomarker to predict which patients might suffer treatment failure. The research was led by Dr. Eugeni Domènech and Dr. Josep Manyé, and published recently in the Journal of Crohn's and Colitis.