At the IGTP TODAY

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- Research

New IGTP spin-off to develop gene therapy for Friedreich’s ataxia, a rare neurodegenerative disease

Biointaxis, the new spin-off company of the IGTP, was recently constituted. The company stems from research led by Dr Antoni Matilla-Dueñas together with Dr Ivelisse Sánchez of the Neurogenetics Group of the IGTP and has been created to increase translational research leading to treatments and new genomic technologies for rare neurological diseases with genetic causes.  The first project the company is undertaking is the development of a gene therapy for Friedreich's Ataxia.

- Research

Overview on recommendations on alcohol consumption for patients with liver disease

Dr Daniel Fuster of the Addiction Unit of the Internal Medicine Service at the Germans Trias i Pujol University Hospital and Research Institute (IGTP) and the Universitat Autònoma de Barcelona has co-authored a landmark review article on alcohol use in patients with chronic liver disease with Dr Jeffrey H Samet of Boston Medical Center and University School of Medicine.  The article has been published in the New England Journal of Medicine.

- Research

Proof of the importance of the Mediterranean diet for adults with diabetes type 1

Researchers at the Biomedical Research Institute of Lleida (IRBLleida), the Germans Trias i Pujol Research Institute (IGTP) and the Spanish Networked Group CIBER Diabetes and Associated Metabolic Diseases (CIBERDEM) have shown that adult patients with diabetes type 1 (DT1) have healthier eating habits and stick closer to the Mediterranean diet than non-diabetic subjects.It has been published in the European Journal of Nutrition and is the first study that tracks the adherence to the Mediterranean diet in this type of patient.A study has also evaluated the positive benefits of exercise for people with diabetes type 1.

- Research

A study in patients with heart failure points to new prognostic markers for the disease

Researchers of the Cardiovascular Disease Group and the CIBERCV Group, led by Dr Antoni Bayés Genís, have advanced the study of prognostic markers for heart failure, a progressive disease and a public health problem of the first order. They have studied monocyte (a type of white blood cell) count and distribution in a cohort of 400 outpatients with heart failure with a view to showing their predictive value. The study has been published in PLoS One.

- Research

A new approach towards developing a vaccine against vivax malaria

A novel study indicates promising avenues in an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study indicates the possibility of using small vesicles (or exosomes) secreted by immature red blood cells as a vaccine platform against malaria. The paper was published in the journal Scientific Reports.

- Research

The GTS Group advances towards a definitive biomarker for Dementia with Lewy Bodies

The Genomics and Transcriptomics of Synucleinopathies Group led by Dr Katrin Beyer has moved closer towards finding a definitive biomarker for dementia with Lewy bodies (DLB).  Their most recent work has been patented and the latest results have been published in the Journal of Alzheimer's Disease.  This is the next step following on from work on new experimental models, biomarkers in blood samples and sleep disorders in dementia patients described earlier this year on this website.

- Campus Can Ruti, Research

Rice against HIV: a three-protein cocktail produced in seeds shows potent HIV neutralization in vitro

Researchers from University of Lleida-Agrotecnio, IrsiCaixa AIDS Research Institute and ICREA obtained for the first time three different anti-HIV proteins from a single transgenic rice plant and crude extracts from it averted HIV from entering in human cells in vitro. Rice components showed an enhancing effect, further helping to block HIV infectivity. Dr Julià Blanco, researcher from the Institut Germans Trias i Pujol at IrsiCaixa, where he leads the Cell Virology and Immunology group, participated in the study.