G-II 1 Immunopathology
The Immunopathology research group is within the Immunology Service of the Germans Trias Hospital. It is made up of an experienced interdisciplinary team that is highly motivated to carry out translational research and give support to clinical teams who are developing their own research projects to examine the mechanisms of the immune response.
In the laboratory there are advanced immunopathology diagnostics services (including: autoimmunity, allergies, immunochemistry, cellular immunology and immunodeficiency, amongst others), histocompatibility and various panels for immune monitoring of immune-mediated illnesses and immunological treatments (immune-modulating drugs, monoclonal antibodies, cellular therapies and other immunotherapeutic procedures). Since 2008 the group has been developing new immune tolerance-inducing therapies.
The team is made up of researchers, pre-doctoral researchers and technicians who carry out prestigious research projects in the national and international arenas. The laboratory is one of 14 centres of European excellence recognized by the Federation of Clinical Immunological Societies (FOCIS). Since2009 it is a Consolidated Group as recognized by the Agency for Management of University and Research Grants of the Generalitat of Catalonia. It is also the coordinator for a European network consisting of the most important groups in the field of tolergenic cellular therapies for autoimmunity, severe allergies and transplants in the field (European Action COST BM1305-AFACTT) (www.afactt.eu; www.cost.eu ).
We are sorry but the web cannot display our current projects or our publications yet. As soon as this function is available we will publish them.
Innovation and Diagnostic Immunology
Modern clinical immunology has to translate the new possibilities for therapies to an optimized personal treatment. This requires knowledge of the immunological status of patients in different pathological situations, selection of the best treatment and monitoring of its efficiency. The aim of this line of research is to identify new biomarkers for diagnostics or monitoring response to treatment and to implement functional immune-phenotypic panels for patients with immune-mediated illnesses and/or in treatment with therapies that target the immune system.
Clinical Epidemiology Research
The objective is to better understand the immunopathology of immuno-mediated illnesses, the predictive value and pathogenicity, diagnostic and/or prognostic values of serological and genetic cellular markers available.
Immune therapies inducing tolerance
The objective is to develop therapeutic strategies to re-establish immunological tolerance to autoantigens (in autoimmune diseases), to allergens (in severe allergies) and to alloantigen (in transplant). At the moment the group is concentrating on autoimmune diseases of the central nervous system (multiple sclerosis).
Neuroimmunology: Cellular tolerance therapy in multiple sclerosis
Research line codirected by Dr C Ramo, Head of the Multiple Sclerosis Unit in the Department of Neuroscience
Link to Dr Ramo’s group (not available at the moment, we are sorry)
From in vitro studies in a mouse model of multiple sclerosis (experimental auto-immune encephalomyelitis) the group has developed a tolerogenic cell product made from autologous dendritic cells obtained from monocytes in the peripheral blood of patients. This therapy has been developed at clinical scale complying with the conditions of Good Manufacturing Practice (GMP) and pending approval by the AEMPS with the aim of carrying out a Phase i/IIa clinical trial soon.
Eva Mª Martínez Cáceres, Principal Investigator
(+34) 93 497 86 66