Functional specialization of human antigen-presenting cells
Host: Nuria Izquierdo, IrsiCaixa
Date and time: | 15.00
Venue: Auditorium, IJC Building, Campus Can Ruti
Summary of the lecture
Dendritic cells (DC) initiate and orient immune responses in lymphoid organs. DC are a heterogeneous population composed of several subsets with distinct phenotype and ontogeny. Mouse DC subsets have been shown to have distinct functions, especially in terms of antigen presentation and T cell stimulation. Whether the same is true for human DC subsets has been unclear. In a series of studies, we have analyzed human DC directly purified from lymphoid organs and tissues, and found that some functional specializations are conserved between mouse and human DC, but others are not. In addition, we have analyzed the role of lymphoid organ macrophages in T cell stimulation. While mouse macrophages are poor antigen-presenting cells, we found that human lymphoid organ macrophages play a key role in the induction of humoral responses. These results will have important implications for the rationale design of therapies based on the modulation of antigen-presenting cells.
Elodie Segura received a Ph.D. in Immunology in 2006 for her work on dendritic cell-derived exosomes, carried out at the Institut Curie in Paris (France) under the supervision of Clotilde Théry. Elodie Segura was then a postdoctoral fellow in José Villadangos' laboratory at the Walter and Eliza Hall Institute in Melbourne (Australia), working on the mechanisms of cross-presentation in murine dendritic cells. In 2010, she returned to Institut Curie in Paris (France) to undertake the analysis of human dendritic cell subsets in the laboratory of Sebastian Amigorena. Since 2013, she is a Principal Investigator within the "Immunity and Cancer" department at Institut Curie. Her work focuses on the biology of human antigen-presenting cells in health and disease. Elodie Segura is the president of the French Dendritic Cell Society, and an Associate Editor at Frontiers in Immunology (section Antigen Presenting Cell Biology).