1- Direct participation with research groups European Organization for Research and Treatment of Cancer (EORTC). Active member of Radiation Oncology and Brain Group. Affiliation number: 381 Co-chairman Brain Group working party of Radiation Oncology Group (ROG) Active and steering committee member of Grupo de Investigación Clínica de Oncología Radioterápica (GICOR) Co- foundation and active of Grup d’Estudi de Gliomes de Barcelona (GEGB) Active member of Rare Cancer Network (RCN) Participation on clinical trials as collaborator with Spanish group of GI tumors (TTD) and breast cancer (GEICAM)

2- Ongoing Trials As first Investigator: GICOR: Prostate cancer in biochemical relapse. Intermittent vs continuous hormonal treatment Protocol “PROST-INT” EORTC Meningioma G2-3 phase II n 22042 EORTC anaplastic glioma n 22054 CATNON Trial EORTC low grade glioma n 22033 Principal Co-investigator: Study SOGUG 07-01: infiltrative bladder cancer. Phase I, conservative approach with sorafenib and radical radiotherapy Study TENOR: radicular pain, epidemiological analysis Proposals: Trial for Glioblastoma with neoadjuvant Temozolomide x 2 cycles, 21 days on, 7 days off and hypofractionated RT. Proposal for cervical cancer EORTC n 55994 Project for a Stereotactic RT unit for clinical and research purposes As collaborator Department: Participation on Head and Neck cancer of SEOM group: cetuximab and taxans with RT (codes ttcc-2007-01 and TTCC-2007-02) Participation on the proposal for a general national clinical trial on primary lymphoma of the central nervous system. Participation on the European survey about Total Skin Irradiation (TSI) as reference Center

3- Quality Assurance. The DRO is continuously updating their QA controls for clinics and technology: ISO 9001 EORTC 22033, Dummy Run EORTC 22042, Dry Run Radiation Beams: calibration and external audit in the MDA Anderson, Houston