The Heart Failure Unit is a multidisciplinary Unit running since 2001, which can be considered pioneer in Spain from the conception, development and performance points of view. Although it was created basically with welfare purposes, among its objectives it is also possible to stand out the performance of clinical investigational studies. Firstly, we evaluated the impact that being managed and treated at the Unit had on the need of heart failure hospital admissions, and also the influence of heart failure on patients’ quality of life. The research line with the greatest number of publications has been that studying the influence of several different parameters on the prognosis of patients with heart failure, such as diabetes, anemia, creatinine clearance, left atrium diameter, body mass index, ant the presence of atrial fibrillation, fragility and depressive symptoms. At the present time, a completely novel study on the serum levels of myostatin (a modulator of muscle catabolism) in patients with different degrees of heart failure is being carried out. Another work line has focused in the study and evaluation of several aspects of knowledge, self-care behaviour and adherence of patients with heart failure and on the impact that educational nurse intervention had on these aspects. We also investigated about differences on heart failure treatment according to sex and age of patients and about cardiovascular and non-cardiovascular causes of death of patients with heart failure. At the present time, the more far-reaching research that is being carried out at the Unit approaches the use of telemedicine tools (communication trough TV and measurement and transmission of parameters such as weight, blood pressure and cardiac pulse from the patients’ home).