G-LD 1 Digestive Inflammatory Pathology Research Group

The translational research that the Inflammatory Intestinal Disease Unit is a multidisciplinary group led from the clinical side by Dr Eugeni Domènech,  Head of the Gastroenterology & Hepatology Department and the  Inflammatory Bowel Diseases Unit at the Hospital Universitari Germans Trias i Pujol and by Dr. Josep Manyé Almero, Principal Investigator for Basic and Translational Research and CIBER-EHD Researcher.  The group is part of the CIBER-EHD Consortium (Spanish Ministry of Science) as well as part of the IBDomics Consortium for genomic research in immune-mediated inflammatory diseases of which Dr. Domènech is the Coordinator for Gastrointestinal diseases.

The Unit has carried out cutting-edge research over the last 25 years which has meant that it has reached a level of excellence in intestinal healthcare and has set a national and international benchmark for the treatment of ulcerative colitis and Crohn's disease.  In recent years the Unit established new lines of research in the field of irritable bowel syndrome and the improvement of therapeutic endoscopy. Understanding, innovating, explaining and training are important and integrated parts of our scientific task with a view to transferring our results to clinical practice. The team combines experts in different skills to ensure that research questions are tackled from the most experimental side (IGTP) to the most clinical side (HUGTP).  The research lines are based on innovative research tools, which allow us to generate new hypotheses aimed at the developmentof a more personalized medicine, better therapies and improved patient management.

Research lines

  • Physiopathology of intestinal inflammatory disease and therapeutic innoation
  • Genetic and functional characterization of phenotypes relevant to clinical practice
  • Post-operative recurrence (POR) of Crohn's disease
  • Determination of biomarkers for POR from omics studies
  • Investigation of the relationship between fibrotic or penetrant complications and the apparition of POR
  • Loss of response to cortiocosteroids in ulcerative colitis

The objective of this line of research is to use systems biology to understand corticosteroid treatment failure.  Researchers will propose new therapeutic tools to combat corticorefractionary responses.  They will determine miRNA profiles that can predict the response to therapy.

  • Neurogastroenterology and Research in endoscopic therapies

This line of research aims to optimize probiotic treatments for irritable bowel syndrome.   Pre-clinical studies will be carried out to improve endoscopic treatment with patches for long-term release of cytostatic or anti-inflammatory drugs.

More information

Contact

Eugeni Domènech Morral and Josep Manyé Almero

Dr Domènech (+34) 93 497 89 09, Dr Manyé (+34) 93 497 86 95

edomenech.germanstrias(ELIMINAR)@gencat.cat

josep.manye(ELIMINAR)@ciberehd.org